Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2850153..2850735 Replicon chromosome
Accession NZ_CP019326
Organism Halomonas sp. 1513

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag BWR19_RS12980 Protein ID WP_076748644.1
Coordinates 2850153..2850434 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BWR19_RS12985 Protein ID WP_076748645.1
Coordinates 2850445..2850735 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWR19_RS19240 2845648..2846379 - 732 WP_156889349.1 hypothetical protein -
BWR19_RS12960 2846573..2847001 - 429 WP_076748641.1 fosfomycin resistance glutathione transferase -
BWR19_RS12965 2847307..2848113 - 807 WP_076748642.1 indole-3-glycerol phosphate synthase TrpC -
BWR19_RS12970 2848150..2849169 - 1020 WP_076748643.1 anthranilate phosphoribosyltransferase -
BWR19_RS12975 2849183..2849770 - 588 WP_076750105.1 aminodeoxychorismate/anthranilate synthase component II -
BWR19_RS12980 2850153..2850434 + 282 WP_076748644.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BWR19_RS12985 2850445..2850735 + 291 WP_076748645.1 HigA family addiction module antidote protein Antitoxin
BWR19_RS12990 2850830..2851078 + 249 Protein_2560 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
BWR19_RS12995 2851242..2852264 - 1023 WP_076748646.1 hypothetical protein -
BWR19_RS13000 2852257..2852766 - 510 WP_076748647.1 hypothetical protein -
BWR19_RS13005 2852824..2853822 - 999 WP_076748648.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2835865..2856429 20564


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(16-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10782.33 Da        Isoelectric Point: 9.9563

>T72252 WP_076748644.1 NZ_CP019326:2850153-2850434 [Halomonas sp. 1513]
MIKSVKDKETASIIRGKLSRKLPHDMQRSALKRLRQLDAAVSLDDLRIPPGNRLEALQGDRGGQYSIRINDQWRLCFRFQ
EGNAYDVEIVDYH

Download         Length: 282 bp

>T72252 NZ_CP019326:2850153-2850434 [Halomonas sp. 1513]
ATGATCAAAAGTGTCAAGGATAAAGAGACGGCCAGCATTATACGCGGCAAGCTCTCCCGAAAATTGCCGCATGATATGCA
GCGAAGCGCGCTCAAGAGACTTCGCCAACTGGATGCAGCCGTCAGCCTTGATGACCTTCGCATTCCACCTGGAAACCGCC
TCGAGGCCCTTCAAGGTGATCGCGGAGGACAATACAGCATACGAATAAACGATCAGTGGCGACTTTGCTTCCGCTTTCAA
GAAGGCAACGCCTATGACGTGGAAATCGTCGACTACCACTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10811.26 Da        Isoelectric Point: 7.2015

>AT72252 WP_076748645.1 NZ_CP019326:2850445-2850735 [Halomonas sp. 1513]
MKTQQLPNIHPGEILLEDFIEPMGLTKNALANAISVPATRIGEITRGARAITADTDLRLSRYFGTSEGYWLRLQNAYDLE
QARRAGRYEEIRPHAA

Download         Length: 291 bp

>AT72252 NZ_CP019326:2850445-2850735 [Halomonas sp. 1513]
ATGAAGACTCAGCAACTACCCAACATACATCCTGGTGAGATCCTGCTAGAGGATTTTATCGAGCCTATGGGGCTCACCAA
GAATGCGCTAGCCAACGCTATCAGCGTACCGGCTACACGGATCGGTGAGATTACCCGCGGCGCACGAGCCATTACCGCCG
ACACCGATCTTCGCCTGTCGCGCTACTTCGGCACCAGCGAAGGTTACTGGCTGCGCCTGCAAAACGCCTATGATCTTGAG
CAAGCACGTCGGGCTGGGCGCTACGAAGAGATACGCCCCCACGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References