Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3082143..3082727 Replicon chromosome
Accession NZ_CP019312
Organism Tateyamaria omphalii strain DOK1-4

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag BWR18_RS15430 Protein ID WP_076629337.1
Coordinates 3082143..3082424 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BWR18_RS15435 Protein ID WP_076629338.1
Coordinates 3082437..3082727 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWR18_RS15400 3077366..3078169 + 804 WP_076630351.1 ABC transporter permease subunit -
BWR18_RS15405 3078174..3078962 + 789 WP_076629333.1 ABC transporter permease subunit -
BWR18_RS15410 3078959..3079990 + 1032 WP_076629334.1 ABC transporter ATP-binding protein -
BWR18_RS15415 3079990..3080805 + 816 WP_076629335.1 phosphodiesterase -
BWR18_RS15425 3081066..3081823 + 758 WP_157598909.1 IS5 family transposase -
BWR18_RS15430 3082143..3082424 + 282 WP_076629337.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BWR18_RS15435 3082437..3082727 + 291 WP_076629338.1 HigA family addiction module antidote protein Antitoxin
BWR18_RS15440 3082815..3083117 + 303 WP_076629339.1 hypothetical protein -
BWR18_RS15445 3083124..3084374 + 1251 WP_083957727.1 S8/S53 family peptidase -
BWR18_RS15460 3085170..3086717 - 1548 WP_076629341.1 relaxase/mobilization nuclease domain-containing protein -
BWR18_RS15465 3086711..3087139 - 429 WP_172839395.1 plasmid mobilization relaxosome protein MobC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 3081066..3085141 4075


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(18-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10246.78 Da        Isoelectric Point: 9.6879

>T72238 WP_076629337.1 NZ_CP019312:3082143-3082424 [Tateyamaria omphalii]
MIQSTKGKLAANAVKGKYGKGFPGDLMKRTRAMLSALDAAVVVEDLRFPPGNHLEELKGDRAGQHSVRINGQWRICFVWT
PNGPADVEIVDYH

Download         Length: 282 bp

>T72238 NZ_CP019312:3082143-3082424 [Tateyamaria omphalii]
ATGATCCAAAGCACCAAGGGCAAACTCGCTGCCAATGCCGTTAAGGGCAAGTATGGCAAAGGCTTCCCGGGTGACTTGAT
GAAGCGCACGCGGGCTATGCTTTCGGCGCTGGATGCTGCGGTTGTTGTCGAGGATTTGCGTTTCCCGCCCGGCAACCACC
TGGAAGAACTGAAAGGGGATCGGGCCGGGCAACACTCCGTGCGGATCAACGGGCAATGGCGCATCTGCTTTGTCTGGACG
CCGAACGGCCCCGCGGATGTCGAGATTGTGGACTACCATTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10667.40 Da        Isoelectric Point: 4.7672

>AT72238 WP_076629338.1 NZ_CP019312:3082437-3082727 [Tateyamaria omphalii]
MSLLEDPMHPGEVLKELYLDPLEMGAIAFARRLGVPRTRIERLIKGTTGITPDTALRLARVFNTTPAYWVNLQTNYDMAL
AAKEIDVSDIEPLVAA

Download         Length: 291 bp

>AT72238 NZ_CP019312:3082437-3082727 [Tateyamaria omphalii]
ATGAGCTTGCTTGAAGACCCGATGCACCCCGGTGAAGTCCTGAAGGAGCTTTACCTCGATCCCTTGGAGATGGGGGCCAT
CGCGTTTGCGCGGCGTCTTGGCGTGCCTCGGACGCGGATCGAGCGGTTGATCAAGGGTACGACGGGTATCACGCCTGACA
CAGCGCTGCGCCTCGCCCGTGTGTTCAACACGACTCCGGCTTACTGGGTGAACTTGCAGACGAACTACGACATGGCGCTA
GCTGCTAAGGAGATTGACGTTTCGGATATTGAGCCGCTTGTGGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References