Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1552968..1553480 Replicon chromosome
Accession NZ_CP019299
Organism Streptococcus pneumoniae strain HKU1-14

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag BWQ98_RS08220 Protein ID WP_000924721.1
Coordinates 1552968..1553222 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag BWQ98_RS08225 Protein ID WP_000388572.1
Coordinates 1553226..1553480 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWQ98_RS08205 1550069..1550383 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
BWQ98_RS08210 1550408..1551034 - 627 WP_000775037.1 guanylate kinase -
BWQ98_RS08215 1551164..1552777 - 1614 WP_127245078.1 ribonuclease Y -
BWQ98_RS08220 1552968..1553222 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
BWQ98_RS08225 1553226..1553480 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BWQ98_RS08230 1553718..1554815 - 1098 WP_000156324.1 nucleotidyltransferase -
BWQ98_RS08235 1554839..1556650 - 1812 WP_001025033.1 NACHT domain-containing protein -
BWQ98_RS08240 1556691..1557431 - 741 WP_050244764.1 class I SAM-dependent methyltransferase -
BWQ98_RS08245 1557751..1558104 - 354 WP_001003001.1 ribosome silencing factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T72230 WP_000924721.1 NZ_CP019299:c1553222-1552968 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T72230 NZ_CP019299:c1553222-1552968 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT72230 WP_000388572.1 NZ_CP019299:c1553480-1553226 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT72230 NZ_CP019299:c1553480-1553226 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References