Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3302034..3302727 Replicon chromosome
Accession NZ_CP019280
Organism Escherichia coli strain 13P484A

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag BWI90_RS17355 Protein ID WP_000415584.1
Coordinates 3302431..3302727 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID -
Locus tag BWI90_RS17350 Protein ID WP_148119789.1
Coordinates 3302034..3302429 (-) Length 132 a.a.

Genomic Context

BWI90_RS17370BWI90_RS17375BWI90_RS17390BWI90_RS17395BWI90_RS17335BWI90_RS17340BWI90_RS17350BWI90_RS17355BWI90_RS17360BWI90_RS17365BWI90_RS17380
Location: 3304011..3304670 (660 bp)
Type: Others
Protein ID: WP_001221493.1
Location: 3304667..3306016 (1350 bp)
Type: Others
Protein ID: WP_000673402.1
Location: 3306714..3307295 (582 bp)
Type: Others
Protein ID: WP_000065430.1
Location: 3307326..3307640 (315 bp)
Type: Others
Protein ID: WP_000958598.1
Location: 3297898..3300156 (2259 bp)
Type: Others
Protein ID: WP_001281841.1
Location: 3300294..3301901 (1608 bp)
Type: Others
Protein ID: WP_001295629.1
Location: 3302034..3302429 (396 bp)
Type: Antitoxin
Protein ID: WP_148119789.1
Location: 3302431..3302727 (297 bp)
Type: Toxin
Protein ID: WP_000415584.1
Location: 3302932..3303414 (483 bp)
Type: Others
Protein ID: WP_000183505.1
Location: 3303467..3303859 (393 bp)
Type: Others
Protein ID: WP_000712658.1
Location: 3306062..3306395 (334 bp)
Type: Others
Protein ID: Protein_3146
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BWI90_RS173353297898..3300156-2259WP_001281841.1DNA topoisomerase IV subunit A-
BWI90_RS173403300294..3301901-1608WP_001295629.1ABC transporter substrate-binding protein-
BWI90_RS173503302034..3302429-396WP_148119789.1type II toxin-antitoxin system antitoxin MqsAAntitoxin
BWI90_RS173553302431..3302727-297WP_000415584.1type II toxin-antitoxin system toxin MqsRToxin
BWI90_RS173603302932..3303414-483WP_000183505.1transcriptional regulator-
BWI90_RS173653303467..3303859-393WP_000712658.1OB fold stress tolerance protein YgiW-
BWI90_RS173703304011..3304670+660WP_001221493.1two-component system response regulator QseB-
BWI90_RS173753304667..3306016+1350WP_000673402.1two-component system sensor histidine kinase QseC-
BWI90_RS173803306062..3306395-334Protein_3146DUF2645 family protein-
BWI90_RS173903306714..3307295+582WP_000065430.1NADPH:quinone oxidoreductase MdaB-
BWI90_RS173953307326..3307640+315WP_000958598.1antibiotic biosynthesis monooxygenase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T72205 WP_000415584.1 NZ_CP019280:c3302727-3302431 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T72205 NZ_CP019280:c3302727-3302431 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14731.15 Da        Isoelectric Point: 9.2136

>AT72205 WP_148119789.1 NZ_CP019280:c3302429-3302034 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNVETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT72205 NZ_CP019280:c3302429-3302034 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGTCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB3HI2

Antitoxin

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Source
ID
Structure
No matching records found

References