Detailed information of TA system TA072185

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1438710..1439081
• Replicon: chromosome
• Accession: NZ_CP019280
• Organism: Escherichia coli strain 13P484A

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A7W3G0W6
• Locus tag: BWI90_RS07565
• Protein ID: WP_072130784.1
• Coordinates: 1438887..1439081 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1438710..1438888 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BWI90_RS07540	1434665..1436038	+	1374	WP_000123737.1	ATP-dependent RNA helicase DbpA	-
BWI90_RS07545	1436167..1437102	-	936	WP_001157377.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
BWI90_RS07550	1437154..1438389	-	1236	WP_000040843.1	site-specific integrase	-
BWI90_RS07555	1438391..1438606	-	216	WP_000079604.1	excisionase XisR	-
BWI90_RS07560	1438706..1438894	-	189	WP_001302840.1	DUF1187 family protein	-
-	1438710..1438888	+	179	NuclAT_0	-	Antitoxin
-	1438710..1438888	+	179	NuclAT_0	-	Antitoxin
-	1438710..1438888	+	179	NuclAT_0	-	Antitoxin
-	1438710..1438888	+	179	NuclAT_0	-	Antitoxin
BWI90_RS07565	1438887..1439081	-	195	WP_072130784.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
BWI90_RS07570	1439138..1439971	-	834	WP_000166322.1	recombination protein RecT	-
BWI90_RS07575	1439964..1442564	-	2601	WP_023281732.1	exodeoxyribonuclease VIII	-
BWI90_RS07580	1442666..1442941	-	276	WP_000632297.1	protein RacC	-
BWI90_RS07585	1443016..1443186	-	171	WP_077897037.1	hypothetical protein	-
BWI90_RS07590	1443186..1443407	-	222	WP_000560223.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1437154..1488099	50945

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7135.00 Da
• Isoelectric Point: 8.0115

>T72185 WP_072130784.1 NZ_CP019280:c1439081-1438887 [Escherichia coli]
MRYDDVKPCPFCGCPSVTVKDISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTENINGGVHV

Nucleotide

• Length: 195 bp

>T72185 NZ_CP019280:c1439081-1438887 [Escherichia coli]
TTGAGATATGACGATGTTAAACCATGTCCGTTTTGTGGTTGTCCATCAGTAACGGTGAAAGACATTTCAGGATATTACCG
GGCAAAATGCAACGGATGCGAATCCCGAACTGGCTATGGTGGAAGTGAAAAAGAAGCGCTCGAAAGATGGAATAAACGAA
CCACTGAAAATATTAATGGAGGCGTTCATGTATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT72185 NZ_CP019280:1438710-1438888 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATTGTAGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A7W3G0W6

Antitoxin