Detailed information of TA system TA072162

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3893116..3893338
• Replicon: chromosome
• Accession: NZ_CP019273
• Organism: Escherichia coli strain 13P477T

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A829L523
• Locus tag: BWI89_RS29340
• Protein ID: WP_000170738.1
• Coordinates: 3893231..3893338 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3893116..3893182 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BWI89_RS20130	3888557..3889459	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
BWI89_RS20135	3889470..3890453	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
BWI89_RS20140	3890450..3891454	+	1005	WP_000107036.1	dipeptide ABC transporter ATP-binding subunit DppF	-
BWI89_RS20145	3891484..3892755	-	1272	WP_001318103.1	amino acid permease	-
-	3893116..3893182	-	67	-	-	Antitoxin
BWI89_RS29340	3893231..3893338	+	108	WP_000170738.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
BWI89_RS20165	3893714..3893821	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
BWI89_RS29345	3894197..3894304	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
BWI89_RS29350	3894680..3894787	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
BWI89_RS20185	3894874..3896553	-	1680	WP_001562264.1	cellulose biosynthesis protein BcsG	-
BWI89_RS20190	3896550..3896741	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
BWI89_RS20195	3896738..3898309	-	1572	WP_001204944.1	cellulose biosynthesis protein BcsE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3864.67 Da
• Isoelectric Point: 9.0157

>T72162 WP_000170738.1 NZ_CP019273:3893231-3893338 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASLIVNWLNKRK

Nucleotide

• Length: 108 bp

>T72162 NZ_CP019273:3893231-3893338 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATAGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT72162 NZ_CP019273:c3893182-3893116 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A829L523

Antitoxin