Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 65892..66318 | Replicon | plasmid p13C1065T-2 |
Accession | NZ_CP019261 | ||
Organism | Escherichia coli strain 13C1065T |
Toxin (Protein)
Gene name | hok | Uniprot ID | P11895 |
Locus tag | BWI86_RS25980 | Protein ID | WP_001312861.1 |
Coordinates | 65892..66050 (-) | Length | 53 a.a. |
Antitoxin (RNA)
Gene name | sok | ||
Locus tag | - | ||
Coordinates | 66094..66318 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BWI86_RS25940 | 61263..61952 | - | 690 | WP_039002187.1 | conjugal transfer transcriptional regulator TraJ | - |
BWI86_RS25945 | 62139..62522 | - | 384 | WP_001151524.1 | relaxosome protein TraM | - |
BWI86_RS25950 | 62843..63445 | + | 603 | WP_000243712.1 | transglycosylase SLT domain-containing protein | - |
BWI86_RS25955 | 63742..64563 | - | 822 | WP_072795862.1 | DUF945 domain-containing protein | - |
BWI86_RS25960 | 64683..64970 | - | 288 | WP_000107535.1 | hypothetical protein | - |
BWI86_RS25980 | 65892..66050 | - | 159 | WP_001312861.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
- | 66094..66318 | - | 225 | NuclAT_0 | - | Antitoxin |
- | 66094..66318 | - | 225 | NuclAT_0 | - | Antitoxin |
- | 66094..66318 | - | 225 | NuclAT_0 | - | Antitoxin |
- | 66094..66318 | - | 225 | NuclAT_0 | - | Antitoxin |
BWI86_RS28840 | 66130..66318 | + | 189 | WP_001299721.1 | hypothetical protein | - |
BWI86_RS25985 | 66330..67049 | - | 720 | WP_001276232.1 | plasmid SOS inhibition protein A | - |
BWI86_RS25990 | 67046..67480 | - | 435 | WP_000845953.1 | conjugation system SOS inhibitor PsiB | - |
BWI86_RS25995 | 67535..69493 | - | 1959 | WP_039000998.1 | ParB/RepB/Spo0J family partition protein | - |
BWI86_RS26000 | 69558..69791 | - | 234 | WP_000005987.1 | DUF905 family protein | - |
BWI86_RS26005 | 69848..70387 | - | 540 | WP_032332913.1 | single-stranded DNA-binding protein | - |
BWI86_RS29230 | 70413..70619 | - | 207 | WP_000275853.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | floR / sul2 / aph(3')-Ia / sul3 / blaTEM-1B / lnu(F) / ant(3'')-Ia / aac(3)-IId / tet(M) / cmlA1 / aadA2 / dfrA12 | - | 1..138610 | 138610 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 53 a.a. Molecular weight: 6082.32 Da Isoelectric Point: 9.2584
>T72056 WP_001312861.1 NZ_CP019261:c66050-65892 [Escherichia coli]
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 159 bp
>T72056 NZ_CP019261:c66050-65892 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG
Antitoxin
Download Length: 225 bp
>AT72056 NZ_CP019261:c66318-66094 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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