Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3933182..3933440 Replicon chromosome
Accession NZ_CP019243
Organism Escherichia coli strain Combat2C1

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag BWI82_RS20180 Protein ID WP_000809168.1
Coordinates 3933182..3933334 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3933383..3933440 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWI82_RS20160 3928427..3929140 - 714 WP_001102393.1 acidic protein MsyB -
BWI82_RS20165 3929166..3929570 - 405 WP_000843689.1 DUF2541 family protein -
BWI82_RS20170 3929942..3931858 + 1917 WP_000516135.1 molecular chaperone DnaK -
BWI82_RS20175 3931947..3933077 + 1131 WP_001118464.1 molecular chaperone DnaJ -
BWI82_RS20180 3933182..3933334 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 3933383..3933440 + 58 - - Antitoxin
BWI82_RS20190 3933949..3934710 + 762 WP_001274828.1 hypothetical protein -
BWI82_RS20195 3934730..3936223 + 1494 WP_001314416.1 sulfatase-like hydrolase/transferase -
BWI82_RS20200 3936352..3937611 + 1260 WP_000494927.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T71929 WP_000809168.1 NZ_CP019243:c3933334-3933182 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T71929 NZ_CP019243:c3933334-3933182 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT71929 NZ_CP019243:3933383-3933440 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References