Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2720029..2720625 Replicon chromosome
Accession NZ_CP019240
Organism Rhodoferax antarcticus strain DSMZ24876

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag RA876_RS13035 Protein ID WP_075587913.1
Coordinates 2720344..2720625 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag RA876_RS13030 Protein ID WP_075587912.1
Coordinates 2720029..2720331 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RA876_RS13015 2715946..2716629 - 684 WP_075587910.1 winged helix-turn-helix domain-containing protein -
RA876_RS13020 2716932..2717354 - 423 WP_075587911.1 DNA-binding protein -
RA876_RS13025 2717477..2719609 + 2133 WP_083634031.1 acyltransferase -
RA876_RS20355 2719771..2719926 + 156 WP_156876250.1 hypothetical protein -
RA876_RS13030 2720029..2720331 - 303 WP_075587912.1 HigA family addiction module antidote protein Antitoxin
RA876_RS13035 2720344..2720625 - 282 WP_075587913.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RA876_RS13040 2720676..2723519 + 2844 Protein_2540 DEAD/DEAH box helicase family protein -
RA876_RS13045 2723613..2724560 - 948 WP_083634032.1 DNA ligase -
RA876_RS13050 2724638..2725195 - 558 WP_075587914.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10906.57 Da        Isoelectric Point: 8.0512

>T71897 WP_075587913.1 NZ_CP019240:c2720625-2720344 [Rhodoferax antarcticus]
VIDSFAHTETERLFLTGKSRRLPPDILRRALMRLTQLHAAMVIDDLRMPPSNRLEALIGDRAGQWRIRINDQWRVCFRFE
DGKALDVEIADYQ

Download         Length: 282 bp

>T71897 NZ_CP019240:c2720625-2720344 [Rhodoferax antarcticus]
GTGATTGACAGCTTTGCGCATACTGAAACCGAACGCTTGTTCTTGACAGGCAAGTCCCGTCGGCTGCCGCCGGACATCCT
GCGTCGGGCTTTGATGCGTTTGACGCAATTGCACGCGGCAATGGTCATTGATGACTTGCGCATGCCGCCATCCAACAGGC
TCGAAGCGTTGATCGGTGACCGCGCTGGGCAATGGCGCATTCGCATCAACGACCAATGGCGTGTGTGCTTTCGGTTTGAG
GATGGAAAAGCGCTTGACGTTGAAATTGCCGACTACCAATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11121.89 Da        Isoelectric Point: 8.6222

>AT71897 WP_075587912.1 NZ_CP019240:c2720331-2720029 [Rhodoferax antarcticus]
MRTLKNGMPPIHPGEFLREILDDLALTQAAFAEAIGISPMRVSHVLRGDRPITAELALRLGRALGQTPQYWLNLQTSYDL
KVAQAEWKDSLRAVRELAAA

Download         Length: 303 bp

>AT71897 NZ_CP019240:c2720331-2720029 [Rhodoferax antarcticus]
ATGCGCACTTTGAAAAATGGAATGCCCCCGATTCACCCCGGCGAATTTCTGCGAGAAATTCTGGATGACTTGGCGTTGAC
GCAGGCGGCCTTTGCCGAGGCCATTGGCATCTCGCCCATGCGCGTGTCGCACGTGCTGCGGGGTGATCGCCCAATTACGG
CCGAACTGGCGCTGCGCTTGGGTCGAGCCTTGGGGCAAACGCCGCAGTACTGGCTCAATCTGCAAACGTCCTACGACTTG
AAAGTGGCGCAAGCCGAATGGAAAGACAGCTTGCGCGCGGTACGGGAGCTGGCTGCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References