Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 462415..463045 Replicon chromosome
Accession NZ_CP019240
Organism Rhodoferax antarcticus strain DSMZ24876

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag RA876_RS02205 Protein ID WP_076071992.1
Coordinates 462713..463045 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag RA876_RS02200 Protein ID WP_076071989.1
Coordinates 462415..462726 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RA876_RS02160 457466..457723 - 258 WP_083633834.1 DUF2442 domain-containing protein -
RA876_RS02165 457695..457934 - 240 WP_075585987.1 DUF4160 domain-containing protein -
RA876_RS02170 458011..458304 - 294 WP_075585988.1 type II toxin-antitoxin system RelE/ParE family toxin -
RA876_RS02175 458301..458525 - 225 WP_075585989.1 addiction module protein -
RA876_RS20155 458918..459115 + 198 WP_156876189.1 hypothetical protein -
RA876_RS02185 459180..459994 + 815 Protein_434 hypothetical protein -
RA876_RS02190 460025..461740 - 1716 WP_075585441.1 IS1634 family transposase -
RA876_RS02195 461908..462354 + 447 WP_076071987.1 maturase -
RA876_RS02200 462415..462726 - 312 WP_076071989.1 helix-turn-helix transcriptional regulator Antitoxin
RA876_RS02205 462713..463045 - 333 WP_076071992.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RA876_RS02210 463197..463829 - 633 WP_076071994.1 hypothetical protein -
RA876_RS20160 464263..464460 + 198 WP_156876189.1 hypothetical protein -
RA876_RS02220 464525..465744 + 1220 Protein_441 group II intron reverse transcriptase/maturase -
RA876_RS02225 465838..466137 - 300 WP_076071997.1 HigA family addiction module antidote protein -
RA876_RS02230 466150..466431 - 282 WP_076072000.1 type II toxin-antitoxin system RelE/ParE family toxin -
RA876_RS02235 466591..466920 - 330 WP_076072002.1 type II toxin-antitoxin system HicB family antitoxin -
RA876_RS02240 466917..467171 - 255 WP_076072005.1 type II toxin-antitoxin system HicA family toxin -
RA876_RS02245 467248..467490 - 243 WP_083639662.1 hypothetical protein -
RA876_RS02250 467483..467758 - 276 WP_076072009.1 BrnT family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 460025..461740 1715


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-88)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12873.25 Da        Isoelectric Point: 10.1866

>T71891 WP_076071992.1 NZ_CP019240:c463045-462713 [Rhodoferax antarcticus]
MKWEIKYHDEKLQADVLALPPGILARYFHCTDRMAEFGPDLGMPHTRAMSLGLFELRLKSREGIGRVFYCTLVDRKIVML
HQFVKKTDKTPPKELALARKRMKEWKNVDA

Download         Length: 333 bp

>T71891 NZ_CP019240:c463045-462713 [Rhodoferax antarcticus]
ATGAAGTGGGAGATCAAATATCACGATGAAAAGTTGCAAGCTGATGTGCTGGCGTTGCCGCCAGGAATTTTGGCTAGGTA
CTTTCATTGCACCGATCGCATGGCAGAGTTCGGCCCTGATTTAGGAATGCCTCACACGCGGGCAATGAGCTTGGGCCTCT
TCGAATTGCGTTTGAAATCCCGTGAGGGCATCGGACGGGTGTTTTACTGCACTTTGGTGGATCGCAAGATCGTCATGCTC
CATCAGTTTGTGAAAAAGACTGATAAGACGCCTCCTAAAGAATTGGCACTTGCGCGCAAGCGAATGAAGGAGTGGAAAAA
TGTTGACGCATAG

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 10.5300

>AT71891 WP_076071989.1 NZ_CP019240:c462726-462415 [Rhodoferax antarcticus]
MLTHRQLRTKALANAEVKAEYEKLADEFSLLDEFLKARAAQGLTQAQVAEKIGTTQSAVARMESGGGRHSPSLATLTKYA
DALGCKLEVRLVRRPRPARNLIG

Download         Length: 312 bp

>AT71891 NZ_CP019240:c462726-462415 [Rhodoferax antarcticus]
ATGTTGACGCATAGACAACTTCGCACCAAGGCACTGGCAAATGCTGAGGTAAAGGCCGAATACGAAAAACTGGCCGATGA
GTTTTCTCTTTTGGACGAGTTCCTGAAGGCGCGGGCTGCCCAGGGTTTAACCCAAGCGCAGGTGGCCGAGAAGATTGGCA
CAACCCAATCCGCCGTAGCACGGATGGAGTCCGGTGGTGGCAGGCACTCGCCATCGCTTGCTACGCTGACCAAGTATGCG
GATGCATTGGGGTGCAAGTTGGAGGTCCGGCTGGTTCGCAGGCCTCGGCCAGCGAGAAATTTAATCGGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References