Detailed information of TA system TA071878

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 444136..444641
• Replicon: chromosome
• Accession: NZ_CP019229
• Organism: Tessaracoccus sp. T2.5-30

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A1C0AML5
• Locus tag: BKM78_RS02140
• Protein ID: WP_068751162.1
• Coordinates: 444136..444402 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A1C0AML7
• Locus tag: BKM78_RS02145
• Protein ID: WP_068751161.1
• Coordinates: 444399..444641 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BKM78_RS02100	439347..440300	-	954	WP_068751170.1	helix-turn-helix domain-containing protein	-
BKM78_RS02105	440405..441040	+	636	WP_068751169.1	isochorismatase family protein	-
BKM78_RS02110	441147..441428	+	282	WP_068751168.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BKM78_RS02115	441442..441744	+	303	WP_068751167.1	HigA family addiction module antidote protein	-
BKM78_RS02120	441828..442148	-	321	WP_068751166.1	DUF86 domain-containing protein	-
BKM78_RS02125	442145..442465	-	321	WP_068751165.1	nucleotidyltransferase domain-containing protein	-
BKM78_RS02130	442556..443074	-	519	WP_068751164.1	hypothetical protein	-
BKM78_RS02135	443286..444032	+	747	WP_068751163.1	hypothetical protein	-
BKM78_RS02140	444136..444402	-	267	WP_068751162.1	Txe/YoeB family addiction module toxin	Toxin
BKM78_RS02145	444399..444641	-	243	WP_068751161.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
BKM78_RS02150	445079..445882	+	804	WP_153302360.1	hypothetical protein	-
BKM78_RS02155	446161..446457	+	297	WP_153302361.1	hypothetical protein	-
BKM78_RS02160	447025..447288	-	264	WP_068750402.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BKM78_RS02165	447285..447557	-	273	WP_068750401.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
BKM78_RS02170	447847..449439	+	1593	WP_141680022.1	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	436809..454093	17284

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10111.75 Da
• Isoelectric Point: 9.9683

>T71878 WP_068751162.1 NZ_CP019229:c444402-444136 [Tessaracoccus sp. T2.5-30]
VSPWTLVYSGQAQKDAKKLASSGLKTKAQHLLEVLAQDPFTTPPKYEKLVGALAGCYSRRINIQHRLVYEVLPERHVVHI
LRMWTHYE

Nucleotide

• Length: 267 bp

>T71878 NZ_CP019229:c444402-444136 [Tessaracoccus sp. T2.5-30]
GTGAGTCCCTGGACTCTGGTGTACTCAGGCCAAGCCCAGAAGGACGCCAAGAAGCTGGCCTCCTCAGGGCTGAAGACGAA
GGCGCAGCACCTGCTAGAGGTTCTGGCCCAGGATCCGTTCACCACCCCACCCAAGTACGAGAAGTTGGTCGGCGCCCTCG
CTGGCTGCTACTCAAGACGCATCAACATCCAGCACCGACTTGTCTATGAGGTGCTCCCTGAGCGCCACGTCGTCCACATC
CTGAGGATGTGGACCCACTACGAGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8689.63 Da
• Isoelectric Point: 3.9421

>AT71878 WP_068751161.1 NZ_CP019229:c444641-444399 [Tessaracoccus sp. T2.5-30]
MTAVSATSARANLYRLIDQVNEESEPLTITGQRGNAVLIGEEDWLAIQETLFLESVPGLADSIRRARAEGVDAGSTELDW

Nucleotide

• Length: 243 bp

>AT71878 NZ_CP019229:c444641-444399 [Tessaracoccus sp. T2.5-30]
ATGACTGCTGTAAGCGCAACGTCTGCCCGCGCGAACCTGTACCGGTTGATCGACCAGGTCAACGAGGAGTCCGAGCCGCT
GACCATCACCGGCCAGCGTGGCAACGCGGTGCTTATCGGCGAGGAGGACTGGCTCGCCATCCAGGAGACACTGTTCCTGG
AGTCGGTACCGGGGTTGGCCGATTCCATCCGGCGCGCCCGCGCGGAGGGCGTCGACGCGGGCTCGACCGAGCTGGACTGG
TGA

Structures

Toxin

• AlphaFold DB: A0A1C0AML5

Antitoxin

• AlphaFold DB: A0A1C0AML7