Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-VapI |
| Location | 441147..441744 | Replicon | chromosome |
| Accession | NZ_CP019229 | ||
| Organism | Tessaracoccus sp. T2.5-30 | ||
Toxin (Protein)
| Gene name | graT | Uniprot ID | A0A1C0AMU7 |
| Locus tag | BKM78_RS02110 | Protein ID | WP_068751168.1 |
| Coordinates | 441147..441428 (+) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | A0A1C0AMI6 |
| Locus tag | BKM78_RS02115 | Protein ID | WP_068751167.1 |
| Coordinates | 441442..441744 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BKM78_RS15080 | 436222..436770 | + | 549 | WP_176715187.1 | NERD domain-containing protein | - |
| BKM78_RS02075 | 436809..437042 | - | 234 | WP_068751174.1 | hypothetical protein | - |
| BKM78_RS02080 | 437175..437738 | - | 564 | WP_068751460.1 | AAA family ATPase | - |
| BKM78_RS02085 | 437858..438436 | + | 579 | WP_068751173.1 | DUF1697 domain-containing protein | - |
| BKM78_RS02090 | 438407..438685 | - | 279 | WP_068751172.1 | helix-turn-helix domain-containing protein | - |
| BKM78_RS02095 | 438702..439226 | - | 525 | WP_141680043.1 | hypothetical protein | - |
| BKM78_RS02100 | 439347..440300 | - | 954 | WP_068751170.1 | helix-turn-helix domain-containing protein | - |
| BKM78_RS02105 | 440405..441040 | + | 636 | WP_068751169.1 | isochorismatase family protein | - |
| BKM78_RS02110 | 441147..441428 | + | 282 | WP_068751168.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| BKM78_RS02115 | 441442..441744 | + | 303 | WP_068751167.1 | HigA family addiction module antidote protein | Antitoxin |
| BKM78_RS02120 | 441828..442148 | - | 321 | WP_068751166.1 | DUF86 domain-containing protein | - |
| BKM78_RS02125 | 442145..442465 | - | 321 | WP_068751165.1 | nucleotidyltransferase domain-containing protein | - |
| BKM78_RS02130 | 442556..443074 | - | 519 | WP_068751164.1 | hypothetical protein | - |
| BKM78_RS02135 | 443286..444032 | + | 747 | WP_068751163.1 | hypothetical protein | - |
| BKM78_RS02140 | 444136..444402 | - | 267 | WP_068751162.1 | Txe/YoeB family addiction module toxin | - |
| BKM78_RS02145 | 444399..444641 | - | 243 | WP_068751161.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| BKM78_RS02150 | 445079..445882 | + | 804 | WP_153302360.1 | hypothetical protein | - |
| BKM78_RS02155 | 446161..446457 | + | 297 | WP_153302361.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 436809..454093 | 17284 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10890.46 Da Isoelectric Point: 9.2303
>T71877 WP_068751168.1 NZ_CP019229:441147-441428 [Tessaracoccus sp. T2.5-30]
VIRSFRDPATERLWSRQRVKSIDPRIERVALRKLVMLDAAEILDDLRIPPGNRLEALRGDRAGQHSIRINQQWRICFTWT
DAGPTDVEIVDYH
VIRSFRDPATERLWSRQRVKSIDPRIERVALRKLVMLDAAEILDDLRIPPGNRLEALRGDRAGQHSIRINQQWRICFTWT
DAGPTDVEIVDYH
Download Length: 282 bp
>T71877 NZ_CP019229:441147-441428 [Tessaracoccus sp. T2.5-30]
GTGATCAGATCCTTCAGGGACCCGGCAACCGAACGGCTCTGGTCACGACAACGGGTCAAGAGCATCGACCCGCGAATCGA
ACGGGTCGCCCTGCGGAAGCTGGTGATGCTGGATGCCGCCGAGATCCTGGATGACCTCCGGATACCTCCCGGCAACCGGC
TCGAGGCACTCCGCGGAGACAGGGCTGGACAGCACAGCATCCGGATCAACCAGCAATGGCGGATCTGCTTCACCTGGACC
GACGCCGGACCCACTGACGTCGAAATCGTCGACTACCACTGA
GTGATCAGATCCTTCAGGGACCCGGCAACCGAACGGCTCTGGTCACGACAACGGGTCAAGAGCATCGACCCGCGAATCGA
ACGGGTCGCCCTGCGGAAGCTGGTGATGCTGGATGCCGCCGAGATCCTGGATGACCTCCGGATACCTCCCGGCAACCGGC
TCGAGGCACTCCGCGGAGACAGGGCTGGACAGCACAGCATCCGGATCAACCAGCAATGGCGGATCTGCTTCACCTGGACC
GACGCCGGACCCACTGACGTCGAAATCGTCGACTACCACTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11430.20 Da Isoelectric Point: 7.3203
>AT71877 WP_068751167.1 NZ_CP019229:441442-441744 [Tessaracoccus sp. T2.5-30]
MTSTTAIPPIHPGEILMDEFLEPLQISQNRLAVAIGVPPRRINEIVHGKRRITADTALRLARYFGTTDRFWLNLQTRFDL
EVEKDHLGNTLDRIEPLKAV
MTSTTAIPPIHPGEILMDEFLEPLQISQNRLAVAIGVPPRRINEIVHGKRRITADTALRLARYFGTTDRFWLNLQTRFDL
EVEKDHLGNTLDRIEPLKAV
Download Length: 303 bp
>AT71877 NZ_CP019229:441442-441744 [Tessaracoccus sp. T2.5-30]
ATGACATCAACAACAGCGATCCCACCGATCCACCCGGGCGAGATCCTGATGGACGAGTTCCTGGAGCCGCTGCAGATCAG
CCAGAACCGGCTCGCCGTCGCGATCGGCGTACCCCCACGTCGGATCAACGAGATCGTGCACGGCAAGCGTCGCATCACGG
CCGACACAGCGCTGCGGCTGGCTCGCTACTTCGGCACCACCGACAGGTTCTGGCTCAACCTCCAGACCCGCTTCGACCTC
GAGGTCGAGAAGGACCACCTCGGCAACACCCTCGACCGGATCGAGCCGCTCAAGGCCGTCTGA
ATGACATCAACAACAGCGATCCCACCGATCCACCCGGGCGAGATCCTGATGGACGAGTTCCTGGAGCCGCTGCAGATCAG
CCAGAACCGGCTCGCCGTCGCGATCGGCGTACCCCCACGTCGGATCAACGAGATCGTGCACGGCAAGCGTCGCATCACGG
CCGACACAGCGCTGCGGCTGGCTCGCTACTTCGGCACCACCGACAGGTTCTGGCTCAACCTCCAGACCCGCTTCGACCTC
GAGGTCGAGAAGGACCACCTCGGCAACACCCTCGACCGGATCGAGCCGCTCAAGGCCGTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1C0AMU7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1C0AMI6 |