Detailed information of TA system TA071828

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 45135..45737
• Replicon: plasmid pCFSAN003307
• Accession: NZ_CP019203
• Organism: Salmonella enterica subsp. enterica serovar Infantis strain CFSAN003307

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: AIM85_RS23390
• Protein ID: WP_001159630.1
• Coordinates: 45135..45446 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: AIM85_RS23395
• Protein ID: WP_000362050.1
• Coordinates: 45447..45737 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AIM85_RS23355	40248..40847	+	600	WP_000965698.1	glucose-1-phosphatase	-
AIM85_RS23360	40841..41713	+	873	WP_000921423.1	virulence factor BrkB family protein	-
AIM85_RS23365	41710..42147	+	438	WP_023993693.1	D-tyrosyl-tRNA(Tyr) deacylase	-
AIM85_RS23370	42192..43133	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
AIM85_RS23375	43148..43594	-	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
AIM85_RS23380	43591..43902	-	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
AIM85_RS23385	43988..44917	-	930	WP_021294279.1	alpha/beta hydrolase	-
AIM85_RS23390	45135..45446	+	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
AIM85_RS23395	45447..45737	+	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
AIM85_RS23400	45784..46713	-	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
AIM85_RS23405	46710..47345	-	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
AIM85_RS23410	47342..48244	-	903	WP_000331361.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..178238	178238

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T71828 WP_001159630.1 NZ_CP019203:45135-45446 [Salmonella enterica subsp. enterica serovar Infantis]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T71828 NZ_CP019203:45135-45446 [Salmonella enterica subsp. enterica serovar Infantis]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT71828 WP_000362050.1 NZ_CP019203:45447-45737 [Salmonella enterica subsp. enterica serovar Infantis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT71828 NZ_CP019203:45447-45737 [Salmonella enterica subsp. enterica serovar Infantis]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64