Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2493123..2493307 Replicon chromosome
Accession NZ_CP019117
Organism Staphylococcus aureus strain SJTUF_J27

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag BRL61_RS13015 Protein ID WP_000482647.1
Coordinates 2493200..2493307 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2493123..2493183 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BRL61_RS12990 2488633..2488800 - 168 Protein_2392 hypothetical protein -
BRL61_RS13000 2489031..2490764 - 1734 WP_000486505.1 ABC transporter ATP-binding protein/permease -
BRL61_RS13005 2490789..2492552 - 1764 WP_053865749.1 ABC transporter ATP-binding protein/permease -
- 2493123..2493183 + 61 - - Antitoxin
BRL61_RS13015 2493200..2493307 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
BRL61_RS13020 2493441..2493827 - 387 WP_000779351.1 flippase GtxA -
BRL61_RS13025 2494095..2495237 + 1143 WP_001176855.1 glycerate kinase -
BRL61_RS13030 2495297..2495956 + 660 WP_000831298.1 membrane protein -
BRL61_RS13035 2496138..2497349 + 1212 WP_001191919.1 multidrug effflux MFS transporter -
BRL61_RS13040 2497472..2497945 - 474 WP_000456496.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T71762 WP_000482647.1 NZ_CP019117:c2493307-2493200 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T71762 NZ_CP019117:c2493307-2493200 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT71762 NZ_CP019117:2493123-2493183 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References