Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2467822..2468339 Replicon chromosome
Accession NZ_CP019117
Organism Staphylococcus aureus strain SJTUF_J27

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag BRL61_RS12855 Protein ID WP_000251928.1
Coordinates 2467822..2468088 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag BRL61_RS12860 Protein ID WP_000584497.1
Coordinates 2468088..2468339 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BRL61_RS12825 2463029..2463565 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
BRL61_RS12835 2464033..2464857 - 825 WP_000594640.1 formate/nitrite transporter family protein -
BRL61_RS12840 2465060..2465242 - 183 WP_000079140.1 hypothetical protein -
BRL61_RS12845 2465329..2465796 - 468 WP_076050741.1 SRPBCC domain-containing protein -
BRL61_RS12850 2465982..2467529 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
BRL61_RS12855 2467822..2468088 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
BRL61_RS12860 2468088..2468339 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BRL61_RS12865 2468503..2468603 - 101 Protein_2370 hypothetical protein -
BRL61_RS12870 2468610..2469209 - 600 WP_000162804.1 DsbA family protein -
BRL61_RS12875 2469228..2469590 - 363 WP_000819843.1 DUF4467 domain-containing protein -
BRL61_RS12880 2469845..2471095 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
BRL61_RS12885 2471192..2471923 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
BRL61_RS12890 2471920..2472639 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T71761 WP_000251928.1 NZ_CP019117:c2468088-2467822 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T71761 NZ_CP019117:c2468088-2467822 [Staphylococcus aureus]
ATGGTTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTAATTAAAAGTATTGACAGAAATGGTGCGTTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT71761 WP_000584497.1 NZ_CP019117:c2468339-2468088 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT71761 NZ_CP019117:c2468339-2468088 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATAGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTGTAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References