Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 71632..72290 Replicon plasmid pMDR-CQ
Accession NZ_CP019115
Organism Acinetobacter baumannii strain MDR-CQ

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BV884_RS19380 Protein ID WP_000312250.1
Coordinates 71931..72290 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BV884_RS19375 Protein ID WP_001096429.1
Coordinates 71632..71931 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV884_RS19335 66797..67426 + 630 WP_000701002.1 hypothetical protein -
BV884_RS19340 67466..67975 + 510 WP_001043200.1 hypothetical protein -
BV884_RS19345 68057..68569 + 513 WP_000840065.1 hypothetical protein -
BV884_RS19350 68613..68954 + 342 WP_002001471.1 hypothetical protein -
BV884_RS19355 68991..69719 + 729 WP_001022819.1 hypothetical protein -
BV884_RS19360 69955..70509 + 555 WP_134232924.1 hypothetical protein -
BV884_RS19365 70559..71095 + 537 WP_000732006.1 hypothetical protein -
BV884_RS19375 71632..71931 - 300 WP_001096429.1 helix-turn-helix transcriptional regulator Antitoxin
BV884_RS19380 71931..72290 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BV884_RS19385 72491..73057 + 567 WP_000710385.1 hypothetical protein -
BV884_RS19390 73106..73288 + 183 WP_000373385.1 hypothetical protein -
BV884_RS19395 73355..74053 + 699 WP_000873188.1 hypothetical protein -
BV884_RS19400 74192..74575 + 384 WP_000654347.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..75390 75390


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T71752 WP_000312250.1 NZ_CP019115:c72290-71931 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T71752 NZ_CP019115:c72290-71931 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGTCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTATGGAGATAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT71752 WP_001096429.1 NZ_CP019115:c71931-71632 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT71752 NZ_CP019115:c71931-71632 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References