Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3852254..3852914 Replicon chromosome
Accession NZ_CP019113
Organism Enterobacter sp. SA187

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BMF08_RS18610 Protein ID WP_072569000.1
Coordinates 3852561..3852914 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BMF08_RS18605 Protein ID WP_072568999.1
Coordinates 3852254..3852556 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMF08_RS18585 3847683..3848762 + 1080 WP_072568995.1 GTP-binding DUF697 domain-containing protein -
BMF08_RS18590 3848887..3849300 - 414 WP_072568996.1 GFA family protein -
BMF08_RS18595 3849597..3851696 - 2100 WP_072568997.1 elongation factor G -
BMF08_RS18600 3851907..3852212 + 306 WP_072568998.1 helix-turn-helix domain-containing protein -
BMF08_RS18605 3852254..3852556 - 303 WP_072568999.1 XRE family transcriptional regulator Antitoxin
BMF08_RS18610 3852561..3852914 - 354 WP_072569000.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BMF08_RS18615 3853124..3854179 - 1056 WP_072569001.1 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase -
BMF08_RS18620 3854200..3854940 - 741 WP_072569002.1 adenosylcobinamide-GDP ribazoletransferase -
BMF08_RS18625 3854937..3855482 - 546 WP_072569003.1 bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase -
BMF08_RS18630 3855479..3857014 - 1536 WP_072569004.1 cobyric acid synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(28-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13551.67 Da        Isoelectric Point: 9.4320

>T71750 WP_072569000.1 NZ_CP019113:c3852914-3852561 [Enterobacter sp. SA187]
MWVIETTDRFDTWYSMQNETDRECILASLLVLRAKGPQLARPYADTIKGSRYANMKELRIQSRGDPIRAFFAFDVMRTGI
VLCAGSKVGNEKRFYDVMLPLAEQEYAEHLKKINRKG

Download         Length: 354 bp

>T71750 NZ_CP019113:c3852914-3852561 [Enterobacter sp. SA187]
ATGTGGGTAATTGAAACAACGGACAGATTCGATACCTGGTACAGCATGCAAAATGAAACCGATCGGGAATGCATTCTGGC
GTCGCTGCTGGTGTTGAGGGCGAAAGGGCCGCAGCTGGCCAGGCCTTATGCAGACACCATCAAAGGTTCACGCTACGCCA
ATATGAAGGAGCTGCGTATCCAGAGTCGCGGCGATCCGATCCGTGCTTTTTTTGCCTTCGATGTTATGCGCACCGGGATC
GTCCTGTGCGCAGGCAGTAAGGTGGGCAATGAGAAACGCTTTTATGATGTGATGCTGCCGCTTGCCGAACAAGAGTATGC
CGAACATCTGAAAAAAATTAACCGTAAGGGGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10895.51 Da        Isoelectric Point: 7.2028

>AT71750 WP_072568999.1 NZ_CP019113:c3852556-3852254 [Enterobacter sp. SA187]
MGRTLTQILAQENPDVVANAEAQAADILLNIHLAELREKVRKTQNDMAQALGVKQPTVAGMEKPGRDLKLSSLKRYVEAA
GGKLRLDIELPDGSHYGFSL

Download         Length: 303 bp

>AT71750 NZ_CP019113:c3852556-3852254 [Enterobacter sp. SA187]
ATGGGAAGAACGCTGACGCAAATTCTGGCGCAGGAAAATCCTGACGTCGTGGCAAACGCCGAAGCGCAGGCGGCGGACAT
TCTGCTTAATATTCATCTTGCCGAGCTGCGTGAAAAAGTGCGCAAAACCCAGAATGACATGGCGCAGGCGCTGGGCGTCA
AACAGCCAACGGTGGCTGGCATGGAGAAACCAGGTCGCGATTTAAAACTTTCATCGTTAAAACGCTACGTTGAGGCGGCG
GGCGGTAAGCTGCGTCTGGATATTGAGCTGCCCGACGGTTCTCATTATGGCTTCAGTCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References