Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 279514..280168 Replicon chromosome
Accession NZ_CP019113
Organism Enterobacter sp. SA187

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BMF08_RS01340 Protein ID WP_072569868.1
Coordinates 279514..279882 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BMF08_RS01345 Protein ID WP_072569867.1
Coordinates 279869..280168 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMF08_RS01335 277357..279159 - 1803 WP_072569869.1 allophanate hydrolase -
BMF08_RS01340 279514..279882 + 369 WP_072569868.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BMF08_RS01345 279869..280168 + 300 WP_072569867.1 XRE family transcriptional regulator Antitoxin
BMF08_RS01350 280251..280523 - 273 WP_072569866.1 N-acetyltransferase -
BMF08_RS01355 280523..280765 - 243 WP_072569865.1 (4Fe-4S)-binding protein -
BMF08_RS01360 280897..281577 - 681 WP_158684867.1 DUF1120 domain-containing protein -
BMF08_RS01365 281640..282299 - 660 WP_072569863.1 DUF1120 domain-containing protein -
BMF08_RS01370 282360..282908 - 549 WP_072569862.1 hypothetical protein -
BMF08_RS01375 282905..284068 - 1164 WP_083580963.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 14275.30 Da        Isoelectric Point: 6.1042

>T71731 WP_072569868.1 NZ_CP019113:279514-279882 [Enterobacter sp. SA187]
VWEIITRKLFDRWFEEQTEEVQEEILAHFVILEEDGPHLGRPQVDQIKGSQYQNMKELRVQVAGHPFRAFFAFDPQRKAI
VLCAADKKGETDKIFYKRMIKIADAEFKSHLKSPEVKENGDA

Download         Length: 369 bp

>T71731 NZ_CP019113:279514-279882 [Enterobacter sp. SA187]
GTGTGGGAAATCATTACGCGAAAGCTGTTTGATAGGTGGTTTGAGGAACAGACCGAGGAAGTACAGGAAGAAATTTTAGC
CCACTTCGTCATTCTCGAAGAGGATGGTCCACACTTAGGACGACCACAGGTAGACCAGATCAAGGGATCGCAATACCAGA
ACATGAAGGAACTTCGCGTACAGGTTGCGGGGCATCCATTCCGGGCATTCTTCGCATTTGATCCGCAGCGAAAAGCGATT
GTGTTATGCGCGGCAGATAAGAAAGGTGAAACGGATAAAATCTTCTATAAACGTATGATTAAGATTGCCGATGCTGAGTT
CAAATCGCATCTGAAATCACCGGAGGTTAAAGAAAATGGCGACGCTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10945.80 Da        Isoelectric Point: 10.3388

>AT71731 WP_072569867.1 NZ_CP019113:279869-280168 [Enterobacter sp. SA187]
MATLKEMMAKRSPESRDRIKARAAEIRQEITLAKLREELNVSQTQLAAALGVSQPSVVKMEKIDNDPKLSTLKRYVTALG
GELTLDVTLPDGKRIALNL

Download         Length: 300 bp

>AT71731 NZ_CP019113:279869-280168 [Enterobacter sp. SA187]
ATGGCGACGCTTAAAGAAATGATGGCTAAACGCTCTCCAGAAAGCCGTGATCGCATAAAGGCGCGTGCCGCTGAAATACG
TCAGGAAATTACCTTAGCGAAACTGCGCGAAGAGCTAAACGTCTCGCAGACACAACTCGCCGCCGCGCTGGGCGTAAGCC
AGCCTTCTGTCGTTAAGATGGAGAAGATCGATAATGACCCGAAACTTTCTACACTCAAGCGCTATGTTACGGCGCTGGGC
GGAGAGTTAACGTTAGATGTTACCCTGCCAGACGGTAAGCGAATTGCGCTTAACCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References