Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1853687..1854189 Replicon chromosome
Accession NZ_CP019071
Organism Escherichia coli strain CRE1493

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag BVL38_RS09380 Protein ID WP_000767829.1
Coordinates 1853935..1854189 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag BVL38_RS09375 Protein ID WP_001259255.1
Coordinates 1853687..1853938 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVL38_RS09345 1848864..1849931 - 1068 WP_000080090.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
BVL38_RS09350 1849931..1851001 - 1071 WP_000108933.1 histidinol-phosphate transaminase -
BVL38_RS09355 1850998..1852302 - 1305 WP_074514295.1 histidinol dehydrogenase -
BVL38_RS09360 1852308..1853207 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
BVL38_RS09370 1853353..1853403 - 51 WP_001364200.1 his operon leader peptide -
BVL38_RS09375 1853687..1853938 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
BVL38_RS09380 1853935..1854189 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
BVL38_RS09385 1854272..1855096 + 825 WP_000754737.1 SDR family oxidoreductase -
BVL38_RS09390 1855142..1856071 + 930 WP_000803366.1 LysR family transcriptional regulator -
BVL38_RS09395 1856286..1856348 + 63 WP_010723108.1 membrane protein YoeI -
BVL38_RS09400 1856338..1857696 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
BVL38_RS09405 1857875..1858933 + 1059 WP_087523589.1 transport protein YeeE -
BVL38_RS09410 1858947..1859174 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-84)

Antitoxin

(1-73)


Sequences


Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T71684 WP_000767829.1 NZ_CP019071:1853935-1854189 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T71684 NZ_CP019071:1853935-1854189 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT71684 WP_001259255.1 NZ_CP019071:1853687-1853938 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT71684 NZ_CP019071:1853687-1853938 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q


Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References