71684

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1853687..1854189 Replicon chromosome
Accession NZ_CP019071
Organism Escherichia coli strain CRE1493

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag BVL38_RS09380 Protein ID WP_000767829.1
Coordinates 1853935..1854189 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag BVL38_RS09375 Protein ID WP_001259255.1
Coordinates 1853687..1853938 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVL38_RS09345 1848864..1849931 - 1068 WP_000080090.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
BVL38_RS09350 1849931..1851001 - 1071 WP_000108933.1 histidinol-phosphate transaminase -
BVL38_RS09355 1850998..1852302 - 1305 WP_074514295.1 histidinol dehydrogenase -
BVL38_RS09360 1852308..1853207 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
BVL38_RS09370 1853353..1853403 - 51 WP_001364200.1 his operon leader peptide -
BVL38_RS09375 1853687..1853938 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
BVL38_RS09380 1853935..1854189 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
BVL38_RS09385 1854272..1855096 + 825 WP_000754737.1 SDR family oxidoreductase -
BVL38_RS09390 1855142..1856071 + 930 WP_000803366.1 LysR family transcriptional regulator -
BVL38_RS09395 1856286..1856348 + 63 WP_010723108.1 membrane protein YoeI -
BVL38_RS09400 1856338..1857696 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
BVL38_RS09405 1857875..1858933 + 1059 WP_087523589.1 transport protein YeeE -
BVL38_RS09410 1858947..1859174 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T71684 WP_000767829.1 NZ_CP019071:1853935-1854189 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T71684 NZ_CP019071:1853935-1854189 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT71684 WP_001259255.1 NZ_CP019071:1853687-1853938 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT71684 NZ_CP019071:1853687-1853938 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References