Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1499715..1500229 Replicon chromosome
Accession NZ_CP019030
Organism Limosilactobacillus fermentum strain SNUV175

Toxin (Protein)


Gene name yoeB Uniprot ID A0A829M010
Locus tag BUW47_RS07625 Protein ID WP_023465988.1
Coordinates 1499966..1500229 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C0WV67
Locus tag BUW47_RS07620 Protein ID WP_003684069.1
Coordinates 1499715..1499969 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BUW47_RS07590 1495000..1495968 + 969 WP_075667500.1 helix-turn-helix domain-containing protein -
BUW47_RS07595 1496028..1496744 + 717 WP_081378690.1 sel1 repeat family protein -
BUW47_RS07600 1496746..1497102 + 357 WP_004562984.1 MmcQ/YjbR family DNA-binding protein -
BUW47_RS07605 1497083..1497500 + 418 Protein_1469 hypothetical protein -
BUW47_RS07610 1497978..1498637 + 660 WP_004562986.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
BUW47_RS07615 1498741..1499553 + 813 WP_023465989.1 family 1 glycosylhydrolase -
BUW47_RS07620 1499715..1499969 + 255 WP_003684069.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BUW47_RS07625 1499966..1500229 + 264 WP_023465988.1 Txe/YoeB family addiction module toxin Toxin
BUW47_RS07630 1500639..1501760 - 1122 WP_081378691.1 PTS sugar transporter subunit IIC -
BUW47_RS07635 1502267..1502392 - 126 Protein_1475 transposase -
BUW47_RS07640 1502397..1503280 + 884 Protein_1476 IS30 family transposase -
BUW47_RS07645 1503332..1503748 + 417 Protein_1477 IS256 family transposase -
BUW47_RS07650 1503940..1504251 + 312 Protein_1478 KxYKxGKxW signal peptide domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-78)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-55)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10267.91 Da        Isoelectric Point: 10.0702

>T71571 WP_023465988.1 NZ_CP019030:1499966-1500229 [Limosilactobacillus fermentum]
MSYAIELKRSANKELKKIKGSYLEKSFLQIIEQLRKDPLAPNQGFEKLVLPIKGFYSRRINIQHRLVYKVDQDTQTVIIY
SAWSHDE

Download         Length: 264 bp

>T71571 NZ_CP019030:1499966-1500229 [Limosilactobacillus fermentum]
ATGAGTTACGCGATTGAACTCAAGCGGAGCGCTAATAAAGAACTCAAGAAAATTAAGGGGTCATATTTAGAAAAGAGCTT
CTTGCAAATAATTGAGCAGCTCCGTAAAGACCCCTTGGCACCCAACCAAGGCTTTGAAAAATTAGTACTGCCAATTAAGG
GCTTTTACTCCCGGCGGATTAACATTCAGCACCGACTCGTCTATAAGGTTGATCAAGACACGCAAACTGTGATCATCTAT
TCTGCGTGGTCACATGACGAATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9745.04 Da        Isoelectric Point: 4.4237

>AT71571 WP_003684069.1 NZ_CP019030:1499715-1499969 [Limosilactobacillus fermentum]
MDQIVTPTQARKDLFKIIKRINENNEPVVIKPTKADEKSVVVIGEDDWKAIQETLFLVNHGVDKQIKERENEPLDDFDDV
WGQL

Download         Length: 255 bp

>AT71571 NZ_CP019030:1499715-1499969 [Limosilactobacillus fermentum]
ATGGACCAAATTGTAACCCCAACGCAAGCACGGAAAGATTTATTCAAAATAATCAAAAGGATCAATGAAAATAATGAGCC
GGTTGTGATTAAGCCGACCAAGGCGGATGAAAAGAGCGTTGTCGTCATTGGTGAAGATGACTGGAAAGCAATCCAAGAAA
CGTTATTTTTGGTTAATCACGGTGTTGACAAGCAAATTAAAGAACGGGAAAACGAGCCGCTCGACGACTTTGATGATGTT
TGGGGTCAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829M010

Antitoxin

Source ID Structure
AlphaFold DB A0A806T868

References