Detailed information of TA system TA071557

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-agrB/SymE(toxin)
• Location: 2406720..2407132
• Replicon: chromosome
• Accession: NZ_CP019029
• Organism: Escherichia coli strain Ecol_881

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: BE930_RS14690
• Protein ID: WP_000132601.1
• Coordinates: 2406791..2407132 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	agrB
Locus tag	-
Coordinates	2406720..2406796 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BE930_RS14680	2403583..2405172	+	1590	WP_001063200.1	type I restriction-modification system methyltransferase	-
BE930_RS14685	2405169..2406563	+	1395	WP_001272445.1	type I restriction-modification system specificity subunit	-
-	2406720..2406796	-	77	NuclAT_7	-	Antitoxin
-	2406720..2406796	-	77	NuclAT_7	-	Antitoxin
-	2406720..2406796	-	77	NuclAT_7	-	Antitoxin
-	2406720..2406796	-	77	NuclAT_7	-	Antitoxin
-	2406720..2406796	-	77	NuclAT_8	-	Antitoxin
-	2406720..2406796	-	77	NuclAT_8	-	Antitoxin
-	2406720..2406796	-	77	NuclAT_8	-	Antitoxin
-	2406720..2406796	-	77	NuclAT_8	-	Antitoxin
BE930_RS14690	2406791..2407132	+	342	WP_000132601.1	endoribonuclease SymE	Toxin
BE930_RS14695	2407294..2408673	+	1380	WP_078207939.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
BE930_RS14700	2408673..2409719	+	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T71557 WP_000132601.1 NZ_CP019029:2406791-2407132 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T71557 NZ_CP019029:2406791-2407132 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT71557 NZ_CP019029:c2406796-2406720 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin