Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yafN-yafO (relBE)/YafO-YafN |
Location | 3095127..3095821 | Replicon | chromosome |
Accession | NZ_CP018995 | ||
Organism | Escherichia coli strain Ecol_AZ147 |
Toxin (Protein)
Gene name | yafO | Uniprot ID | S1EXB8 |
Locus tag | BE962_RS18490 | Protein ID | WP_001263493.1 |
Coordinates | 3095127..3095525 (-) | Length | 133 a.a. |
Antitoxin (Protein)
Gene name | yafN | Uniprot ID | S1FJN6 |
Locus tag | BE962_RS18495 | Protein ID | WP_000554757.1 |
Coordinates | 3095528..3095821 (-) | Length | 98 a.a. |
Genomic Context
Location: 3092182..3093639 (1458 bp)
Type: Others
Protein ID: WP_001293009.1
Type: Others
Protein ID: WP_001293009.1
Location: 3090127..3091371 (1245 bp)
Type: Others
Protein ID: WP_000189541.1
Type: Others
Protein ID: WP_000189541.1
Location: 3090787..3090867 (81 bp)
Type: Others
Protein ID: NuclAT_12
Type: Others
Protein ID: NuclAT_12
Location: 3090787..3090867 (81 bp)
Type: Others
Protein ID: NuclAT_12
Type: Others
Protein ID: NuclAT_12
Location: 3090787..3090867 (81 bp)
Type: Others
Protein ID: NuclAT_12
Type: Others
Protein ID: NuclAT_12
Location: 3090787..3090867 (81 bp)
Type: Others
Protein ID: NuclAT_12
Type: Others
Protein ID: NuclAT_12
Location: 3091463..3091921 (459 bp)
Type: Others
Protein ID: WP_001291990.1
Type: Others
Protein ID: WP_001291990.1
Location: 3093696..3094217 (522 bp)
Type: Others
Protein ID: Protein_2950
Type: Others
Protein ID: Protein_2950
Location: 3094216..3094419 (204 bp)
Type: Others
Protein ID: Protein_2951
Type: Others
Protein ID: Protein_2951
Location: 3094665..3095117 (453 bp)
Type: Others
Protein ID: WP_001059847.1
Type: Others
Protein ID: WP_001059847.1
Location: 3095127..3095525 (399 bp)
Type: Toxin
Protein ID: WP_001263493.1
Type: Toxin
Protein ID: WP_001263493.1
Location: 3095528..3095821 (294 bp)
Type: Antitoxin
Protein ID: WP_000554757.1
Type: Antitoxin
Protein ID: WP_000554757.1
Location: 3095873..3096928 (1056 bp)
Type: Others
Protein ID: WP_001226164.1
Type: Others
Protein ID: WP_001226164.1
Location: 3096999..3097922 (924 bp)
Type: Others
Protein ID: WP_001232547.1
Type: Others
Protein ID: WP_001232547.1
Location: 3097925..3098788 (864 bp)
Type: Others
Protein ID: WP_001169518.1
Type: Others
Protein ID: WP_001169518.1
Location: 3098801..3099517 (717 bp)
Type: Others
Protein ID: WP_000938723.1
Type: Others
Protein ID: WP_000938723.1
Location: 3099537..3100004 (468 bp)
Type: Others
Protein ID: WP_000725257.1
Type: Others
Protein ID: WP_000725257.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BE962_RS18460 | 3090127..3091371 | - | 1245 | WP_000189541.1 | esterase FrsA | - |
- | 3090787..3090867 | - | 81 | NuclAT_12 | - | - |
- | 3090787..3090867 | - | 81 | NuclAT_12 | - | - |
- | 3090787..3090867 | - | 81 | NuclAT_12 | - | - |
- | 3090787..3090867 | - | 81 | NuclAT_12 | - | - |
BE962_RS18465 | 3091463..3091921 | - | 459 | WP_001291990.1 | xanthine phosphoribosyltransferase | - |
BE962_RS18470 | 3092182..3093639 | + | 1458 | WP_001293009.1 | cytosol nonspecific dipeptidase | - |
BE962_RS18475 | 3093696..3094217 | - | 522 | Protein_2950 | peptide chain release factor H | - |
BE962_RS18480 | 3094216..3094419 | - | 204 | Protein_2951 | RNA ligase RtcB family protein | - |
BE962_RS18485 | 3094665..3095117 | - | 453 | WP_001059847.1 | GNAT family N-acetyltransferase | - |
BE962_RS18490 | 3095127..3095525 | - | 399 | WP_001263493.1 | type II toxin-antitoxin system mRNA interferase toxin YafO | Toxin |
BE962_RS18495 | 3095528..3095821 | - | 294 | WP_000554757.1 | type I toxin-antitoxin system antitoxin YafN | Antitoxin |
BE962_RS18500 | 3095873..3096928 | - | 1056 | WP_001226164.1 | DNA polymerase IV | - |
BE962_RS18505 | 3096999..3097922 | - | 924 | WP_001232547.1 | putative lateral flagellar export/assembly protein LafU | - |
BE962_RS18510 | 3097925..3098788 | - | 864 | WP_001169518.1 | flagellar motor stator protein MotA | - |
BE962_RS18515 | 3098801..3099517 | - | 717 | WP_000938723.1 | FliA/WhiG family RNA polymerase sigma factor | - |
BE962_RS18520 | 3099537..3100004 | - | 468 | WP_000725257.1 | flagellar basal body-associated FliL family protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 3042807..3096928 | 54121 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15472.83 Da Isoelectric Point: 8.0949
>T71321 WP_001263493.1 NZ_CP018995:c3095525-3095127 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF
Download Length: 399 bp
>T71321 NZ_CP018995:c3095525-3095127 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11233.81 Da Isoelectric Point: 5.9050
>AT71321 WP_000554757.1 NZ_CP018995:c3095821-3095528 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
Download Length: 294 bp
>AT71321 NZ_CP018995:c3095821-3095528 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA