Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3095127..3095821 Replicon chromosome
Accession NZ_CP018995
Organism Escherichia coli strain Ecol_AZ147

Toxin (Protein)


Gene name yafO Uniprot ID S1EXB8
Locus tag BE962_RS18490 Protein ID WP_001263493.1
Coordinates 3095127..3095525 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1FJN6
Locus tag BE962_RS18495 Protein ID WP_000554757.1
Coordinates 3095528..3095821 (-) Length 98 a.a.

Genomic Context


BE962_RS18470BE962_RS18460----BE962_RS18465BE962_RS18475BE962_RS18480BE962_RS18485BE962_RS18490BE962_RS18495BE962_RS18500BE962_RS18505BE962_RS18510BE962_RS18515BE962_RS18520
Location: 3092182..3093639 (1458 bp)
Type: Others
Protein ID: WP_001293009.1
Location: 3090127..3091371 (1245 bp)
Type: Others
Protein ID: WP_000189541.1
Location: 3090787..3090867 (81 bp)
Type: Others
Protein ID: NuclAT_12
Location: 3090787..3090867 (81 bp)
Type: Others
Protein ID: NuclAT_12
Location: 3090787..3090867 (81 bp)
Type: Others
Protein ID: NuclAT_12
Location: 3090787..3090867 (81 bp)
Type: Others
Protein ID: NuclAT_12
Location: 3091463..3091921 (459 bp)
Type: Others
Protein ID: WP_001291990.1
Location: 3093696..3094217 (522 bp)
Type: Others
Protein ID: Protein_2950
Location: 3094216..3094419 (204 bp)
Type: Others
Protein ID: Protein_2951
Location: 3094665..3095117 (453 bp)
Type: Others
Protein ID: WP_001059847.1
Location: 3095127..3095525 (399 bp)
Type: Toxin
Protein ID: WP_001263493.1
Location: 3095528..3095821 (294 bp)
Type: Antitoxin
Protein ID: WP_000554757.1
Location: 3095873..3096928 (1056 bp)
Type: Others
Protein ID: WP_001226164.1
Location: 3096999..3097922 (924 bp)
Type: Others
Protein ID: WP_001232547.1
Location: 3097925..3098788 (864 bp)
Type: Others
Protein ID: WP_001169518.1
Location: 3098801..3099517 (717 bp)
Type: Others
Protein ID: WP_000938723.1
Location: 3099537..3100004 (468 bp)
Type: Others
Protein ID: WP_000725257.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BE962_RS184603090127..3091371-1245WP_000189541.1esterase FrsA-
-3090787..3090867-81NuclAT_12--
-3090787..3090867-81NuclAT_12--
-3090787..3090867-81NuclAT_12--
-3090787..3090867-81NuclAT_12--
BE962_RS184653091463..3091921-459WP_001291990.1xanthine phosphoribosyltransferase-
BE962_RS184703092182..3093639+1458WP_001293009.1cytosol nonspecific dipeptidase-
BE962_RS184753093696..3094217-522Protein_2950peptide chain release factor H-
BE962_RS184803094216..3094419-204Protein_2951RNA ligase RtcB family protein-
BE962_RS184853094665..3095117-453WP_001059847.1GNAT family N-acetyltransferase-
BE962_RS184903095127..3095525-399WP_001263493.1type II toxin-antitoxin system mRNA interferase toxin YafOToxin
BE962_RS184953095528..3095821-294WP_000554757.1type I toxin-antitoxin system antitoxin YafNAntitoxin
BE962_RS185003095873..3096928-1056WP_001226164.1DNA polymerase IV-
BE962_RS185053096999..3097922-924WP_001232547.1putative lateral flagellar export/assembly protein LafU-
BE962_RS185103097925..3098788-864WP_001169518.1flagellar motor stator protein MotA-
BE962_RS185153098801..3099517-717WP_000938723.1FliA/WhiG family RNA polymerase sigma factor-
BE962_RS185203099537..3100004-468WP_000725257.1flagellar basal body-associated FliL family protein-

Associated MGEs


Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--3042807..309692854121


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(27-130)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 133 a.a.        Molecular weight: 15472.83 Da        Isoelectric Point: 8.0949

>T71321 WP_001263493.1 NZ_CP018995:c3095525-3095127 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

>T71321 NZ_CP018995:c3095525-3095127 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.81 Da        Isoelectric Point: 5.9050

>AT71321 WP_000554757.1 NZ_CP018995:c3095821-3095528 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE

Download         Length: 294 bp

>AT71321 NZ_CP018995:c3095821-3095528 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBS1EXB8


Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBS1FJN6

References