Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2135178..2135871 Replicon chromosome
Accession NZ_CP018965
Organism Escherichia coli strain Ecol_517

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag BE959_RS12100 Protein ID WP_000415585.1
Coordinates 2135178..2135474 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag BE959_RS12105 Protein ID WP_000650107.1
Coordinates 2135476..2135871 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BE959_RS26070 2130312..2131504 + 1193 Protein_1961 Hcp family type VI secretion system effector -
BE959_RS12075 2131511..2131843 + 333 WP_000914690.1 DUF2645 family protein -
BE959_RS12080 2131889..2133238 - 1350 WP_000673358.1 two-component system sensor histidine kinase QseC -
BE959_RS12085 2133235..2133894 - 660 WP_001221502.1 two-component system response regulator QseB -
BE959_RS12090 2134046..2134438 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
BE959_RS12095 2134491..2134973 + 483 WP_000183505.1 transcriptional regulator -
BE959_RS12100 2135178..2135474 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
BE959_RS12105 2135476..2135871 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
BE959_RS12110 2136004..2137611 + 1608 WP_001375094.1 ABC transporter substrate-binding protein -
BE959_RS12115 2137749..2140007 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T71089 WP_000415585.1 NZ_CP018965:2135178-2135474 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T71089 NZ_CP018965:2135178-2135474 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT71089 WP_000650107.1 NZ_CP018965:2135476-2135871 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT71089 NZ_CP018965:2135476-2135871 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References