Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 34852..35509 | Replicon | plasmid pEC316_KPC |
| Accession | NZ_CP018956 | ||
| Organism | Escherichia coli strain Ecol_316 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | BE963_RS01580 | Protein ID | WP_000270043.1 |
| Coordinates | 34852..35202 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | BE963_RS01585 | Protein ID | WP_000124640.1 |
| Coordinates | 35207..35509 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BE963_RS01540 | 31326..31823 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| BE963_RS01545 | 31826..32314 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| BE963_RS01550 | 32411..32746 | + | 336 | WP_000683476.1 | hypothetical protein | - |
| BE963_RS01555 | 32761..33231 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| BE963_RS01560 | 33224..33595 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| BE963_RS01565 | 33606..33800 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| BE963_RS01575 | 34141..34689 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| BE963_RS01580 | 34852..35202 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| BE963_RS01585 | 35207..35509 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| BE963_RS01590 | 35536..35829 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| BE963_RS01595 | 35917..36189 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| BE963_RS01600 | 36247..36792 | - | 546 | WP_032413569.1 | thermonuclease family protein | - |
| BE963_RS01610 | 36916..37896 | - | 981 | WP_012569499.1 | IS5-like element ISKpn26 family transposase | - |
| BE963_RS01615 | 37991..38179 | - | 189 | WP_001270411.1 | hypothetical protein | - |
| BE963_RS01620 | 38205..39062 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| BE963_RS01625 | 39049..39279 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| BE963_RS01630 | 39279..39797 | - | 519 | WP_000210758.1 | nitrite reductase | - |
| BE963_RS01635 | 39794..40240 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaTEM-1D / ant(2'')-Ia / aac(6')-33 / qacE / sul1 / blaKPC-2 / sul2 / floR | - | 1..216226 | 216226 | |
| - | flank | IS/Tn | - | - | 36916..37896 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T71042 WP_000270043.1 NZ_CP018956:34852-35202 [Escherichia coli]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T71042 NZ_CP018956:34852-35202 [Escherichia coli]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT71042 WP_000124640.1 NZ_CP018956:35207-35509 [Escherichia coli]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT71042 NZ_CP018956:35207-35509 [Escherichia coli]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|