Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1..265 Replicon plasmid pEC224_2
Accession NZ_CP018946
Organism Escherichia coli strain Ecol_224

Toxin (Protein)


Gene name pndA Uniprot ID U9Z417
Locus tag BE957_RS00645 Protein ID WP_001387489.1
Coordinates 1..153 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 205..265 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BE957_RS00645 1..153 - 153 WP_001387489.1 Hok/Gef family protein Toxin
- 205..265 + 61 NuclAT_0 - Antitoxin
- 205..265 + 61 NuclAT_0 - Antitoxin
- 205..265 + 61 NuclAT_0 - Antitoxin
- 205..265 + 61 NuclAT_0 - Antitoxin
BE957_RS00650 468..1559 + 1092 WP_031942446.1 hypothetical protein -
- 1629..1686 + 58 NuclAT_1 - -
- 1629..1686 + 58 NuclAT_1 - -
- 1629..1686 + 58 NuclAT_1 - -
- 1629..1686 + 58 NuclAT_1 - -
BE957_RS00655 1866..3074 + 1209 WP_001611760.1 IncI1-type conjugal transfer protein TrbA -
BE957_RS00660 3093..4163 + 1071 WP_078207108.1 IncI1-type conjugal transfer protein TrbB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..87114 87114


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5761.10 Da        Isoelectric Point: 8.7948

>T70959 WP_001387489.1 NZ_CP018946:c153-1 [Escherichia coli]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T70959 NZ_CP018946:c153-1 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 61 bp

>AT70959 NZ_CP018946:205-265 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9Z417

Antitoxin

Download structure file

References