Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3426006..3426658 Replicon chromosome
Accession NZ_CP018929
Organism Serratia marcescens strain UMH11

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BVG89_RS16305 Protein ID WP_049206122.1
Coordinates 3426006..3426350 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BVG89_RS16310 Protein ID WP_025304078.1
Coordinates 3426356..3426658 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG89_RS16295 3422349..3424607 - 2259 WP_089181236.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
BVG89_RS16300 3424828..3425847 + 1020 WP_028127674.1 HTH-type transcriptional regulator GalR -
BVG89_RS16305 3426006..3426350 + 345 WP_049206122.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BVG89_RS16310 3426356..3426658 + 303 WP_025304078.1 helix-turn-helix transcriptional regulator Antitoxin
BVG89_RS16315 3426686..3427948 - 1263 WP_043139806.1 diaminopimelate decarboxylase -
BVG89_RS16320 3428082..3429005 + 924 WP_043139803.1 LysR family transcriptional regulator -
BVG89_RS16325 3429033..3429941 - 909 WP_033644836.1 LysR family transcriptional regulator -
BVG89_RS16330 3430050..3430934 + 885 WP_025304082.1 MBL fold metallo-hydrolase -
BVG89_RS16335 3431003..3431650 + 648 WP_043139796.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(29-89)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13283.28 Da        Isoelectric Point: 10.8296

>T70931 WP_049206122.1 NZ_CP018929:3426006-3426350 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLARPHADTLHFSDAARQLKELRVQHRGRPFRGFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

>T70931 NZ_CP018929:3426006-3426350 [Serratia marcescens]
ATGTGGCAAGTGGTGACCGTCGAACGGTTCGACGACTGGTTTTTAGCGCTGAACAACGCCCAGCAAACCAGCATCCTGGC
GGCGATCTTCAAATTACAGACGTTCGGCCCGCAGTTGGCGCGGCCGCACGCCGATACGCTGCATTTTTCCGACGCGGCCC
GGCAGTTGAAGGAGCTGCGCGTTCAACATCGCGGGCGCCCTTTCAGAGGGTTTTTCGCTTTTGACCCACAGCGGCAAGCG
GTATTGCTGTGCGGCGGCGATAAAACTGGCGACAAACGCTTTTACCAGCGCATGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11081.01 Da        Isoelectric Point: 10.3986

>AT70931 WP_025304078.1 NZ_CP018929:3426356-3426658 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp

>AT70931 NZ_CP018929:3426356-3426658 [Serratia marcescens]
ATGGCCAAACCGTTATCCCAACTGATCGATAAACTCGATCCCGCCGTCGTTGCCGCAGCCAGGCAAAAAGCGGACAAGGA
AATTTTCGAGCTGCGGCTGGCAATGCTGAGGGAAGAGCTGGCGGTCTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATAAAGCTGTCGTCGCTCAAACGCTATATCGAGGCGATG
GGCGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAGCACCGCCGCATGACGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References