Detailed information of TA system TA070877

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2865280..2865940
• Replicon: chromosome
• Accession: NZ_CP018925
• Organism: Serratia marcescens strain UMH3

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: BVG91_RS14040
• Protein ID: WP_043147691.1
• Coordinates: 2865587..2865940 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A2V4GQ69
• Locus tag: BVG91_RS14035
• Protein ID: WP_033635213.1
• Coordinates: 2865280..2865582 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BVG91_RS14015	2860911..2861825	-	915	WP_004928592.1	branched-chain amino acid ABC transporter permease	-
BVG91_RS14020	2861950..2863068	-	1119	WP_033647954.1	branched-chain amino acid ABC transporter substrate-binding protein	-
BVG91_RS14030	2863672..2864880	-	1209	WP_043147690.1	aldose 1-epimerase family protein	-
BVG91_RS14035	2865280..2865582	-	303	WP_033635213.1	XRE family transcriptional regulator	Antitoxin
BVG91_RS14040	2865587..2865940	-	354	WP_043147691.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BVG91_RS14045	2866380..2867675	+	1296	WP_043147692.1	MFS transporter	-
BVG91_RS14050	2867703..2868509	+	807	WP_060419116.1	substrate-binding domain-containing protein	-
BVG91_RS14055	2868484..2869383	-	900	WP_043147695.1	LysR family transcriptional regulator	-
BVG91_RS14060	2869476..2869841	-	366	WP_033635218.1	diacylglycerol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-89)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13432.24 Da
• Isoelectric Point: 7.9895

>T70877 WP_043147691.1 NZ_CP018925:c2865940-2865587 [Serratia marcescens]
VWEIKTTDAFDNWFSSLHDADRAGVLAALMILREKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDQMIQAADREFTNWLNTLNEKE

Nucleotide

• Length: 354 bp

>T70877 NZ_CP018925:c2865940-2865587 [Serratia marcescens]
GTGTGGGAAATTAAAACAACGGATGCGTTTGATAACTGGTTTAGCTCACTCCACGATGCCGATCGGGCTGGCGTGCTTGC
CGCATTGATGATCCTGCGGGAAAAGGGGCCGGGGCTGCCCAGACCCTATGCCGATACGGTTAAAGGTTCGCGTTACAGCA
ATATGAAAGAGCTGCGCATTCAGAGCCGTGGCGAACCGTTGCGGGCATTCTTCGCCTTCGATCCGTACCGTATCGGCATT
GTACTTTGCGCGGGCAATAAAGCCGGTAATGAAAAACGTTTTTACGATCAGATGATTCAGGCTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11079.94 Da
• Isoelectric Point: 6.4738

>AT70877 WP_033635213.1 NZ_CP018925:c2865582-2865280 [Serratia marcescens]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Nucleotide

• Length: 303 bp

>AT70877 NZ_CP018925:c2865582-2865280 [Serratia marcescens]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAAGCGCTGGCGGCTGACAT
CATGCTGAACATCCACCTTGCCGAGCTGCGCGAGAAGGTGCAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGTATCC
GGCAACCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTAAAACGCTATGTTGAGGCGGCC
GGCGGCAAGCTGCGCCTGGATGTTGAACTGCCGGACGGCTCTCACTACGAATTTGTGCTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2V4GQ69