Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2776573..2777230 Replicon chromosome
Accession NZ_CP018925
Organism Serratia marcescens strain UMH3

Toxin (Protein)


Gene name higB Uniprot ID A0A0M4RY59
Locus tag BVG91_RS13610 Protein ID WP_060420873.1
Coordinates 2776907..2777230 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0M5M3W3
Locus tag BVG91_RS13605 Protein ID WP_060420390.1
Coordinates 2776573..2776869 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG91_RS13580 2772097..2772732 + 636 WP_060437753.1 flavodoxin family protein -
BVG91_RS13585 2772876..2773985 + 1110 WP_060419067.1 glycosyltransferase family 9 protein -
BVG91_RS13590 2773915..2775132 - 1218 WP_060419069.1 O-antigen ligase family protein -
BVG91_RS13595 2775110..2776018 - 909 WP_060419071.1 sugar glycosyltransferase -
BVG91_RS13600 2776323..2776565 + 243 WP_025303447.1 hypothetical protein -
BVG91_RS13605 2776573..2776869 - 297 WP_060420390.1 helix-turn-helix domain-containing protein Antitoxin
BVG91_RS13610 2776907..2777230 - 324 WP_060420873.1 toxin HigB-2 Toxin
BVG91_RS13615 2777295..2777924 - 630 WP_060425958.1 hypothetical protein -
BVG91_RS13620 2778010..2778945 + 936 WP_049212009.1 LysR family transcriptional regulator -
BVG91_RS13625 2778928..2779575 - 648 WP_019452474.1 DNA oxidative demethylase AlkB -
BVG91_RS13630 2779715..2780593 + 879 WP_049273981.1 EamA family transporter RarD -
BVG91_RS13635 2780595..2781353 - 759 WP_039565253.1 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-83)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12370.15 Da        Isoelectric Point: 8.8132

>T70876 WP_060420873.1 NZ_CP018925:c2777230-2776907 [Serratia marcescens]
MDYLEFIETTVFSRKRAELMKDDDFQAFQSYLLLNHHEGDTISHTGGCKKIRWGLDGKGKRGGVRVIYYLTAPSGRVYLL
LIYRKNEKDDLSGQEKAILRSIVQQLD

Download         Length: 324 bp

>T70876 NZ_CP018925:c2777230-2776907 [Serratia marcescens]
ATGGACTATCTGGAGTTTATCGAAACGACCGTTTTCAGCCGAAAGCGGGCTGAATTGATGAAGGATGATGACTTTCAGGC
TTTCCAAAGCTATTTGCTGTTGAACCATCATGAAGGGGATACGATCAGCCACACGGGCGGATGCAAAAAGATACGCTGGG
GGCTGGACGGAAAGGGAAAACGCGGCGGCGTAAGAGTGATTTATTATCTGACGGCGCCCAGCGGCCGAGTCTATTTATTG
TTGATATACCGTAAAAATGAAAAGGATGATTTATCCGGACAGGAAAAGGCGATATTGAGATCCATCGTTCAACAACTTGA
TTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11003.00 Da        Isoelectric Point: 10.1906

>AT70876 WP_060420390.1 NZ_CP018925:c2776869-2776573 [Serratia marcescens]
MKKELFDDLVSSMNEMVAIEKGKMTPKSEHVHRHAIPDVKLLRKSRGMKQAEFAKAVGASVGLVQSWEQERRIPSGSALK
LLLLIERNPALLDELLVI

Download         Length: 297 bp

>AT70876 NZ_CP018925:c2776869-2776573 [Serratia marcescens]
ATGAAAAAAGAACTTTTCGACGATTTGGTCAGTAGTATGAACGAAATGGTGGCGATCGAAAAGGGTAAGATGACGCCAAA
ATCCGAGCATGTTCACCGTCATGCTATTCCAGACGTCAAGCTGCTGCGCAAATCCCGTGGGATGAAGCAGGCGGAGTTTG
CCAAGGCTGTGGGGGCCAGCGTGGGACTGGTGCAAAGCTGGGAGCAGGAACGCCGCATACCCTCGGGGTCGGCACTGAAA
CTTCTGCTGCTGATTGAGCGTAACCCGGCATTGCTCGATGAGTTGCTGGTGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4RY59

Antitoxin

Source ID Structure
AlphaFold DB A0A0M5M3W3

References