Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 4914519..4915172 | Replicon | chromosome |
Accession | NZ_CP018923 | ||
Organism | Serratia marcescens strain UMH9 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | BVG96_RS23115 | Protein ID | WP_060430834.1 |
Coordinates | 4914519..4914869 (+) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A5C7DBM3 |
Locus tag | BVG96_RS23120 | Protein ID | WP_019453270.1 |
Coordinates | 4914873..4915172 (+) | Length | 100 a.a. |
Genomic Context
Location: 4912541..4912858 (318 bp)
Type: Others
Protein ID: WP_041037744.1
Type: Others
Protein ID: WP_041037744.1
Location: 4914519..4914869 (351 bp)
Type: Toxin
Protein ID: WP_060430834.1
Type: Toxin
Protein ID: WP_060430834.1
Location: 4914873..4915172 (300 bp)
Type: Antitoxin
Protein ID: WP_019453270.1
Type: Antitoxin
Protein ID: WP_019453270.1
Location: 4916248..4916946 (699 bp)
Type: Others
Protein ID: WP_060430838.1
Type: Others
Protein ID: WP_060430838.1
Location: 4916958..4917611 (654 bp)
Type: Others
Protein ID: WP_060430840.1
Type: Others
Protein ID: WP_060430840.1
Location: 4917625..4918809 (1185 bp)
Type: Others
Protein ID: WP_060430842.1
Type: Others
Protein ID: WP_060430842.1
Location: 4918828..4919751 (924 bp)
Type: Others
Protein ID: WP_039567560.1
Type: Others
Protein ID: WP_039567560.1
Location: 4909784..4910473 (690 bp)
Type: Others
Protein ID: WP_060430826.1
Type: Others
Protein ID: WP_060430826.1
Location: 4910486..4910896 (411 bp)
Type: Others
Protein ID: WP_060430828.1
Type: Others
Protein ID: WP_060430828.1
Location: 4910925..4912295 (1371 bp)
Type: Others
Protein ID: WP_041037742.1
Type: Others
Protein ID: WP_041037742.1
Location: 4912849..4913244 (396 bp)
Type: Others
Protein ID: WP_060430830.1
Type: Others
Protein ID: WP_060430830.1
Location: 4913244..4914248 (1005 bp)
Type: Others
Protein ID: WP_060430832.1
Type: Others
Protein ID: WP_060430832.1
Location: 4915162..4916079 (918 bp)
Type: Others
Protein ID: WP_060430836.1
Type: Others
Protein ID: WP_060430836.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BVG96_RS23085 | 4909784..4910473 | - | 690 | WP_060430826.1 | trehalose-6-phosphate synthase | - |
BVG96_RS23090 | 4910486..4910896 | - | 411 | WP_060430828.1 | GNAT family N-acetyltransferase | - |
BVG96_RS23095 | 4910925..4912295 | - | 1371 | WP_041037742.1 | glutamine synthetase family protein | - |
BVG96_RS23100 | 4912541..4912858 | + | 318 | WP_041037744.1 | hypothetical protein | - |
BVG96_RS23105 | 4912849..4913244 | - | 396 | WP_060430830.1 | hypothetical protein | - |
BVG96_RS23110 | 4913244..4914248 | - | 1005 | WP_060430832.1 | hypothetical protein | - |
BVG96_RS23115 | 4914519..4914869 | + | 351 | WP_060430834.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
BVG96_RS23120 | 4914873..4915172 | + | 300 | WP_019453270.1 | XRE family transcriptional regulator | Antitoxin |
BVG96_RS23125 | 4915162..4916079 | - | 918 | WP_060430836.1 | LysR family transcriptional regulator | - |
BVG96_RS23130 | 4916248..4916946 | + | 699 | WP_060430838.1 | CoA transferase subunit A | - |
BVG96_RS23135 | 4916958..4917611 | + | 654 | WP_060430840.1 | CoA transferase subunit B | - |
BVG96_RS23140 | 4917625..4918809 | + | 1185 | WP_060430842.1 | acetyl-CoA C-acetyltransferase | - |
BVG96_RS23145 | 4918828..4919751 | + | 924 | WP_039567560.1 | 3-hydroxyacyl-CoA dehydrogenase family protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13526.73 Da Isoelectric Point: 8.2699
>T70864 WP_060430834.1 NZ_CP018923:4914519-4914869 [Serratia marcescens]
MWTVMTTEEFDRWLCEQDESTQEKVLAALVMLERAGPSLRRPFVDVLKGSLHSNMKELRIQHKGRPIRAFFAFDPARQAI
VLCAGDKTGNEKRFYKVMLSIADAQFTQYLMCYFKE
MWTVMTTEEFDRWLCEQDESTQEKVLAALVMLERAGPSLRRPFVDVLKGSLHSNMKELRIQHKGRPIRAFFAFDPARQAI
VLCAGDKTGNEKRFYKVMLSIADAQFTQYLMCYFKE
Download Length: 351 bp
>T70864 NZ_CP018923:4914519-4914869 [Serratia marcescens]
ATGTGGACGGTAATGACAACGGAAGAGTTTGATCGGTGGCTCTGTGAACAGGATGAATCGACGCAGGAAAAGGTGTTGGC
CGCGCTGGTGATGCTCGAGCGTGCAGGGCCTTCTCTTCGGCGGCCTTTTGTCGACGTGCTGAAAGGCTCGTTGCATTCCA
ACATGAAAGAGCTGCGTATTCAGCACAAAGGGCGGCCGATTCGCGCTTTTTTCGCCTTTGATCCGGCGCGGCAGGCGATT
GTGCTGTGTGCGGGCGACAAAACGGGTAATGAGAAGCGGTTTTATAAAGTGATGCTGTCCATCGCGGATGCGCAGTTCAC
CCAATATTTGATGTGTTATTTCAAGGAGTAA
ATGTGGACGGTAATGACAACGGAAGAGTTTGATCGGTGGCTCTGTGAACAGGATGAATCGACGCAGGAAAAGGTGTTGGC
CGCGCTGGTGATGCTCGAGCGTGCAGGGCCTTCTCTTCGGCGGCCTTTTGTCGACGTGCTGAAAGGCTCGTTGCATTCCA
ACATGAAAGAGCTGCGTATTCAGCACAAAGGGCGGCCGATTCGCGCTTTTTTCGCCTTTGATCCGGCGCGGCAGGCGATT
GTGCTGTGTGCGGGCGACAAAACGGGTAATGAGAAGCGGTTTTATAAAGTGATGCTGTCCATCGCGGATGCGCAGTTCAC
CCAATATTTGATGTGTTATTTCAAGGAGTAA
Antitoxin
Download Length: 100 a.a. Molecular weight: 11013.71 Da Isoelectric Point: 7.3207
>AT70864 WP_019453270.1 NZ_CP018923:4914873-4915172 [Serratia marcescens]
MSTLKQLLASRTPESRRRIEEMAEEMLFEAHLHQLREALNISQQELAKTLGISQPSVAAIEGRGNELKISTLKRYVEAMG
GTLRLDVELPGGKHVGFTV
MSTLKQLLASRTPESRRRIEEMAEEMLFEAHLHQLREALNISQQELAKTLGISQPSVAAIEGRGNELKISTLKRYVEAMG
GTLRLDVELPGGKHVGFTV
Download Length: 300 bp
>AT70864 NZ_CP018923:4914873-4915172 [Serratia marcescens]
ATGAGCACCTTAAAGCAACTGCTGGCCTCCCGCACCCCGGAGAGCCGCCGGCGCATCGAGGAAATGGCCGAAGAGATGCT
GTTTGAAGCGCACCTGCACCAGCTGCGGGAAGCGCTGAATATTTCCCAACAGGAACTGGCGAAAACGCTGGGTATTTCCC
AGCCTTCTGTCGCGGCCATTGAAGGGCGCGGCAATGAGCTGAAGATTTCGACCCTGAAACGCTACGTGGAAGCGATGGGC
GGCACGCTGCGCCTGGACGTTGAGCTGCCGGGCGGCAAGCACGTCGGGTTTACGGTTTAA
ATGAGCACCTTAAAGCAACTGCTGGCCTCCCGCACCCCGGAGAGCCGCCGGCGCATCGAGGAAATGGCCGAAGAGATGCT
GTTTGAAGCGCACCTGCACCAGCTGCGGGAAGCGCTGAATATTTCCCAACAGGAACTGGCGAAAACGCTGGGTATTTCCC
AGCCTTCTGTCGCGGCCATTGAAGGGCGCGGCAATGAGCTGAAGATTTCGACCCTGAAACGCTACGTGGAAGCGATGGGC
GGCACGCTGCGCCTGGACGTTGAGCTGCCGGGCGGCAAGCACGTCGGGTTTACGGTTTAA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
No matching records found |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5C7DBM3 |