Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4914519..4915172 Replicon chromosome
Accession NZ_CP018923
Organism Serratia marcescens strain UMH9

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BVG96_RS23115 Protein ID WP_060430834.1
Coordinates 4914519..4914869 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A5C7DBM3
Locus tag BVG96_RS23120 Protein ID WP_019453270.1
Coordinates 4914873..4915172 (+) Length 100 a.a.

Genomic Context


BVG96_RS23100BVG96_RS23115BVG96_RS23120BVG96_RS23130BVG96_RS23135BVG96_RS23140BVG96_RS23145BVG96_RS23085BVG96_RS23090BVG96_RS23095BVG96_RS23105BVG96_RS23110BVG96_RS23125
Location: 4912541..4912858 (318 bp)
Type: Others
Protein ID: WP_041037744.1
Location: 4914519..4914869 (351 bp)
Type: Toxin
Protein ID: WP_060430834.1
Location: 4914873..4915172 (300 bp)
Type: Antitoxin
Protein ID: WP_019453270.1
Location: 4916248..4916946 (699 bp)
Type: Others
Protein ID: WP_060430838.1
Location: 4916958..4917611 (654 bp)
Type: Others
Protein ID: WP_060430840.1
Location: 4917625..4918809 (1185 bp)
Type: Others
Protein ID: WP_060430842.1
Location: 4918828..4919751 (924 bp)
Type: Others
Protein ID: WP_039567560.1
Location: 4909784..4910473 (690 bp)
Type: Others
Protein ID: WP_060430826.1
Location: 4910486..4910896 (411 bp)
Type: Others
Protein ID: WP_060430828.1
Location: 4910925..4912295 (1371 bp)
Type: Others
Protein ID: WP_041037742.1
Location: 4912849..4913244 (396 bp)
Type: Others
Protein ID: WP_060430830.1
Location: 4913244..4914248 (1005 bp)
Type: Others
Protein ID: WP_060430832.1
Location: 4915162..4916079 (918 bp)
Type: Others
Protein ID: WP_060430836.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BVG96_RS230854909784..4910473-690WP_060430826.1trehalose-6-phosphate synthase-
BVG96_RS230904910486..4910896-411WP_060430828.1GNAT family N-acetyltransferase-
BVG96_RS230954910925..4912295-1371WP_041037742.1glutamine synthetase family protein-
BVG96_RS231004912541..4912858+318WP_041037744.1hypothetical protein-
BVG96_RS231054912849..4913244-396WP_060430830.1hypothetical protein-
BVG96_RS231104913244..4914248-1005WP_060430832.1hypothetical protein-
BVG96_RS231154914519..4914869+351WP_060430834.1type II toxin-antitoxin system RelE/ParE family toxinToxin
BVG96_RS231204914873..4915172+300WP_019453270.1XRE family transcriptional regulatorAntitoxin
BVG96_RS231254915162..4916079-918WP_060430836.1LysR family transcriptional regulator-
BVG96_RS231304916248..4916946+699WP_060430838.1CoA transferase subunit A-
BVG96_RS231354916958..4917611+654WP_060430840.1CoA transferase subunit B-
BVG96_RS231404917625..4918809+1185WP_060430842.1acetyl-CoA C-acetyltransferase-
BVG96_RS231454918828..4919751+924WP_039567560.13-hydroxyacyl-CoA dehydrogenase family protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-106)

Antitoxin

(32-83)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 13526.73 Da        Isoelectric Point: 8.2699

>T70864 WP_060430834.1 NZ_CP018923:4914519-4914869 [Serratia marcescens]
MWTVMTTEEFDRWLCEQDESTQEKVLAALVMLERAGPSLRRPFVDVLKGSLHSNMKELRIQHKGRPIRAFFAFDPARQAI
VLCAGDKTGNEKRFYKVMLSIADAQFTQYLMCYFKE

Download         Length: 351 bp

>T70864 NZ_CP018923:4914519-4914869 [Serratia marcescens]
ATGTGGACGGTAATGACAACGGAAGAGTTTGATCGGTGGCTCTGTGAACAGGATGAATCGACGCAGGAAAAGGTGTTGGC
CGCGCTGGTGATGCTCGAGCGTGCAGGGCCTTCTCTTCGGCGGCCTTTTGTCGACGTGCTGAAAGGCTCGTTGCATTCCA
ACATGAAAGAGCTGCGTATTCAGCACAAAGGGCGGCCGATTCGCGCTTTTTTCGCCTTTGATCCGGCGCGGCAGGCGATT
GTGCTGTGTGCGGGCGACAAAACGGGTAATGAGAAGCGGTTTTATAAAGTGATGCTGTCCATCGCGGATGCGCAGTTCAC
CCAATATTTGATGTGTTATTTCAAGGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11013.71 Da        Isoelectric Point: 7.3207

>AT70864 WP_019453270.1 NZ_CP018923:4914873-4915172 [Serratia marcescens]
MSTLKQLLASRTPESRRRIEEMAEEMLFEAHLHQLREALNISQQELAKTLGISQPSVAAIEGRGNELKISTLKRYVEAMG
GTLRLDVELPGGKHVGFTV

Download         Length: 300 bp

>AT70864 NZ_CP018923:4914873-4915172 [Serratia marcescens]
ATGAGCACCTTAAAGCAACTGCTGGCCTCCCGCACCCCGGAGAGCCGCCGGCGCATCGAGGAAATGGCCGAAGAGATGCT
GTTTGAAGCGCACCTGCACCAGCTGCGGGAAGCGCTGAATATTTCCCAACAGGAACTGGCGAAAACGCTGGGTATTTCCC
AGCCTTCTGTCGCGGCCATTGAAGGGCGCGGCAATGAGCTGAAGATTTCGACCCTGAAACGCTACGTGGAAGCGATGGGC
GGCACGCTGCGCCTGGACGTTGAGCTGCCGGGCGGCAAGCACGTCGGGTTTACGGTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
No matching records found


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5C7DBM3

References