Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4037450..4038180 Replicon chromosome
Accession NZ_CP018917
Organism Serratia marcescens strain UMH5

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BVG97_RS19505 Protein ID WP_084827498.1
Coordinates 4037450..4037761 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BVG97_RS19510 Protein ID WP_084827497.1
Coordinates 4037758..4038180 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG97_RS19475 4032761..4033486 + 726 WP_004937040.1 LPS export ABC transporter ATP-binding protein -
BVG97_RS19480 4033539..4034972 + 1434 WP_049198529.1 RNA polymerase factor sigma-54 -
BVG97_RS19485 4034996..4035283 + 288 WP_004937038.1 ribosome hibernation promoting factor -
BVG97_RS19490 4035439..4035900 + 462 WP_016930212.1 PTS IIA-like nitrogen regulatory protein PtsN -
BVG97_RS19495 4036030..4036884 + 855 WP_015379177.1 RNase adapter RapZ -
BVG97_RS19500 4036881..4037153 + 273 WP_004937034.1 PTS phosphocarrier protein NPr -
BVG97_RS19505 4037450..4037761 + 312 WP_084827498.1 type II toxin-antitoxin system HigB family toxin Toxin
BVG97_RS19510 4037758..4038180 + 423 WP_084827497.1 helix-turn-helix domain-containing protein Antitoxin
BVG97_RS19515 4038185..4040101 - 1917 WP_089186491.1 BglG family transcription antiterminator -
BVG97_RS19520 4040153..4041367 - 1215 WP_089186492.1 lactonase family protein -
BVG97_RS19530 4041527..4042267 - 741 WP_089186494.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(81-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12305.18 Da        Isoelectric Point: 10.0957

>T70844 WP_084827498.1 NZ_CP018917:4037450-4037761 [Serratia marcescens]
MHIISRELFNNATKQYPNEAAALEAIYKTLRRGEFRTPDELKALFPSLDRMKYKEKWWVIDVGGNHLRILFFASFETQKV
FIKHIVSHAEYDKLMQHYRRSSS

Download         Length: 312 bp

>T70844 NZ_CP018917:4037450-4037761 [Serratia marcescens]
ATGCATATCATTTCCAGGGAACTGTTCAATAACGCAACGAAGCAATACCCTAATGAAGCCGCTGCTCTCGAGGCCATTTA
TAAAACGTTGCGACGCGGCGAGTTCCGCACGCCGGACGAGTTAAAAGCGCTTTTTCCTTCGCTCGATCGTATGAAATACA
AAGAGAAATGGTGGGTCATTGACGTCGGCGGCAACCACCTGCGAATTTTGTTCTTTGCCAGCTTTGAGACACAGAAAGTA
TTCATAAAGCACATTGTTAGCCACGCCGAGTACGACAAGCTGATGCAGCACTATCGAAGGAGTTCATCATGA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15701.98 Da        Isoelectric Point: 4.7939

>AT70844 WP_084827497.1 NZ_CP018917:4037758-4038180 [Serratia marcescens]
MITDAIKAADALLRAVPLLQGSDSQQDYREALELVEYLLENDEHHPLIDMLAKKIAEYEDNGAEFTAFNQRIAQLPQGVA
ALRVLMEQHQLSQSDFEHEIGKKSLVNQILSGKRSLTIPHIMALAKRFNLPPALFLPEAD

Download         Length: 423 bp

>AT70844 NZ_CP018917:4037758-4038180 [Serratia marcescens]
ATGATTACAGATGCCATTAAGGCCGCCGATGCGCTGCTGCGCGCCGTGCCCTTATTGCAGGGCAGCGATTCTCAGCAAGA
CTACCGGGAAGCGCTCGAATTGGTGGAATATCTGCTGGAAAACGATGAACACCATCCGCTGATTGACATGCTGGCAAAAA
AGATCGCCGAATATGAAGATAACGGCGCCGAGTTTACCGCATTCAACCAGCGTATCGCCCAACTCCCGCAGGGGGTGGCC
GCGCTTCGCGTATTGATGGAACAGCACCAACTCAGCCAAAGTGATTTTGAACATGAGATCGGCAAAAAGTCGTTGGTCAA
CCAAATCCTAAGCGGCAAAAGATCGCTGACCATTCCGCACATTATGGCGCTGGCCAAACGCTTCAATCTGCCCCCGGCCC
TCTTTCTGCCGGAAGCAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References