Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2725845..2726502 Replicon chromosome
Accession NZ_CP018917
Organism Serratia marcescens strain UMH5

Toxin (Protein)


Gene name higB Uniprot ID A0A0M4RY59
Locus tag BVG97_RS13190 Protein ID WP_060420873.1
Coordinates 2726179..2726502 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0M5M3W3
Locus tag BVG97_RS13185 Protein ID WP_060420390.1
Coordinates 2725845..2726141 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG97_RS13160 2721363..2721998 + 636 WP_089186164.1 flavodoxin family protein -
BVG97_RS13165 2722142..2723257 + 1116 WP_089186165.1 glycosyltransferase family 9 protein -
BVG97_RS13170 2723181..2724404 - 1224 WP_060439553.1 O-antigen ligase family protein -
BVG97_RS13175 2724382..2725290 - 909 WP_089186166.1 sugar glycosyltransferase -
BVG97_RS13180 2725595..2725837 + 243 WP_025303447.1 hypothetical protein -
BVG97_RS13185 2725845..2726141 - 297 WP_060420390.1 helix-turn-helix domain-containing protein Antitoxin
BVG97_RS13190 2726179..2726502 - 324 WP_060420873.1 toxin HigB-2 Toxin
BVG97_RS13195 2726567..2727196 - 630 WP_089186167.1 hypothetical protein -
BVG97_RS13200 2727282..2728217 + 936 WP_033647920.1 LysR family transcriptional regulator -
BVG97_RS13205 2728200..2728847 - 648 WP_019452474.1 DNA oxidative demethylase AlkB -
BVG97_RS13210 2728987..2729865 + 879 WP_049273981.1 EamA family transporter RarD -
BVG97_RS13215 2729867..2730625 - 759 WP_039565253.1 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-83)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12370.15 Da        Isoelectric Point: 8.8132

>T70837 WP_060420873.1 NZ_CP018917:c2726502-2726179 [Serratia marcescens]
MDYLEFIETTVFSRKRAELMKDDDFQAFQSYLLLNHHEGDTISHTGGCKKIRWGLDGKGKRGGVRVIYYLTAPSGRVYLL
LIYRKNEKDDLSGQEKAILRSIVQQLD

Download         Length: 324 bp

>T70837 NZ_CP018917:c2726502-2726179 [Serratia marcescens]
ATGGACTATCTGGAGTTTATCGAAACGACCGTTTTCAGCCGAAAGCGGGCTGAATTGATGAAGGATGATGACTTTCAGGC
TTTCCAAAGCTATTTGCTGTTGAACCATCATGAAGGGGATACGATCAGCCACACGGGCGGATGCAAAAAGATACGCTGGG
GGCTGGACGGAAAGGGAAAACGCGGCGGCGTAAGAGTGATTTATTATCTGACGGCGCCCAGCGGCCGAGTCTATTTATTG
TTGATATACCGTAAAAATGAAAAGGATGATTTATCCGGACAGGAAAAGGCGATATTGAGATCCATCGTTCAACAACTTGA
TTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11003.00 Da        Isoelectric Point: 10.1906

>AT70837 WP_060420390.1 NZ_CP018917:c2726141-2725845 [Serratia marcescens]
MKKELFDDLVSSMNEMVAIEKGKMTPKSEHVHRHAIPDVKLLRKSRGMKQAEFAKAVGASVGLVQSWEQERRIPSGSALK
LLLLIERNPALLDELLVI

Download         Length: 297 bp

>AT70837 NZ_CP018917:c2726141-2725845 [Serratia marcescens]
ATGAAAAAAGAACTTTTCGACGATTTGGTCAGCAGTATGAACGAAATGGTGGCGATCGAAAAGGGTAAGATGACGCCAAA
ATCCGAGCATGTTCACCGTCATGCTATTCCAGACGTCAAGCTGCTGCGCAAATCCCGTGGGATGAAGCAGGCGGAGTTTG
CCAAGGCTGTGGGGGCCAGCGTGGGACTGGTGCAAAGCTGGGAGCAGGAACGCCGCATACCCTCGGGGTCGGCACTGAAA
CTTCTGCTGCTGATTGAGCGTAACCCGGCATTGCTCGATGAGTTGCTGGTGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4RY59

Antitoxin

Source ID Structure
AlphaFold DB A0A0M5M3W3

References