Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 28497..29101 Replicon chromosome
Accession NZ_CP018911
Organism Glycocaulis alkaliphilus strain 6B-8

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag X907_RS00155 Protein ID WP_127565054.1
Coordinates 28497..28823 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag X907_RS00160 Protein ID WP_127569199.1
Coordinates 28889..29101 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
X907_RS00130 24135..25160 + 1026 WP_127565049.1 aspartate-semialdehyde dehydrogenase -
X907_RS00135 25160..26302 + 1143 WP_127565050.1 acyl-CoA dehydrogenase family protein -
X907_RS00140 26419..26688 - 270 WP_127565051.1 BolA family transcriptional regulator -
X907_RS00145 26742..27368 + 627 WP_127565052.1 DnaJ domain-containing protein -
X907_RS00150 27476..28471 + 996 WP_127565053.1 cobaltochelatase subunit CobS -
X907_RS00155 28497..28823 + 327 WP_127565054.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
X907_RS00160 28889..29101 + 213 WP_127569199.1 helix-turn-helix domain-containing protein Antitoxin
X907_RS00165 29105..29485 - 381 WP_127565055.1 type II toxin-antitoxin system VapC family toxin -
X907_RS00170 29482..29748 - 267 WP_127565056.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
X907_RS00175 29882..31816 + 1935 WP_127565057.1 cobaltochelatase subunit CobT -
X907_RS00180 31940..33631 - 1692 WP_127565058.1 amidohydrolase -
X907_RS00185 33745..34038 - 294 WP_127565059.1 50S ribosomal protein L28 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(8-59)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12218.34 Da        Isoelectric Point: 10.7725

>T70801 WP_127565054.1 NZ_CP018911:28497-28823 [Glycocaulis alkaliphilus]
MSWTVETLNAEVDAELDALPADMRARFTRIAQLIESVGLTHIGMPHVRPLESGLWEMRMTGRDGIARAIYVTRTGRRVIV
VGAFVKKTQTTPRREIEMALKRAKEIMP

Download         Length: 327 bp

>T70801 NZ_CP018911:28497-28823 [Glycocaulis alkaliphilus]
ATGAGCTGGACCGTCGAAACACTGAATGCCGAGGTTGATGCGGAACTCGACGCCCTGCCGGCGGACATGCGCGCCCGCTT
CACCCGTATTGCGCAGCTGATTGAATCGGTAGGTCTGACGCATATCGGCATGCCGCATGTCCGCCCGCTGGAATCCGGAT
TGTGGGAGATGCGCATGACAGGCCGGGACGGTATCGCCCGGGCCATCTATGTCACCCGCACAGGCCGGCGGGTTATCGTG
GTCGGGGCCTTTGTGAAAAAGACCCAGACAACGCCAAGGCGCGAAATCGAGATGGCGCTGAAGCGGGCAAAGGAGATCAT
GCCGTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7556.63 Da        Isoelectric Point: 8.8548

>AT70801 WP_127569199.1 NZ_CP018911:28889-29101 [Glycocaulis alkaliphilus]
MADEFAVAHALIEARTRAGLSQAELAERMETSQSVIARMESGRHLPSTRSLQRYAHAVGARLNIALVPAA

Download         Length: 213 bp

>AT70801 NZ_CP018911:28889-29101 [Glycocaulis alkaliphilus]
ATGGCGGATGAGTTTGCGGTAGCGCACGCGCTCATCGAAGCGCGCACGCGCGCGGGACTTAGCCAGGCTGAACTCGCCGA
GCGCATGGAAACCAGCCAGTCGGTTATCGCGCGTATGGAGAGCGGGCGCCATCTGCCCTCGACCCGCTCCCTGCAACGCT
ACGCACACGCCGTAGGCGCGCGGCTGAATATTGCGCTGGTGCCAGCAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References