Detailed information of TA system TA070790

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 938931..939528
• Replicon: chromosome
• Accession: NZ_CP018907
• Organism: Neisseria meningitidis strain M21273

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0Y6JZK6
• Locus tag: BVD88_RS05655
• Protein ID: WP_002242826.1
• Coordinates: 939250..939528 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BVD88_RS05650
• Protein ID: WP_002221020.1
• Coordinates: 938931..939242 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BVD88_RS13250	934810..934974	+	165	WP_002224559.1	baseplate J/gp47 family protein	-
BVD88_RS05625	934974..935585	+	612	WP_002224558.1	baseplate J/gp47 family protein	-
BVD88_RS05630	935582..936142	+	561	WP_002213590.1	YmfQ family protein	-
BVD88_RS05635	936153..938126	+	1974	WP_002221022.1	pyocin knob domain-containing protein	-
BVD88_RS05650	938931..939242	-	312	WP_002221020.1	HigA family addiction module antidote protein	Antitoxin
BVD88_RS05655	939250..939528	-	279	WP_002242826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BVD88_RS05660	939613..940218	+	606	WP_002219301.1	hypothetical protein	-
BVD88_RS05665	940197..940493	+	297	WP_002221017.1	hypothetical protein	-
BVD88_RS05670	940490..940699	+	210	WP_002221016.1	hypothetical protein	-
BVD88_RS05675	940809..941951	-	1143	WP_002221015.1	ABC transporter ATP-binding protein/permease	-
BVD88_RS05690	942394..943041	-	648	WP_002217218.1	DUF799 domain-containing protein	-
BVD88_RS05695	943038..943406	-	369	WP_002219297.1	DUF4810 domain-containing protein	-
BVD88_RS05700	943416..944087	-	672	WP_002217215.1	CsgG/HfaB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	924565..940493	15928
	-	flank	IS/Tn	-	-	933780..934745	965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.66 Da
• Isoelectric Point: 10.0980

>T70790 WP_002242826.1 NZ_CP018907:c939528-939250 [Neisseria meningitidis]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T70790 NZ_CP018907:c939528-939250 [Neisseria meningitidis]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCCGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11476.32 Da
• Isoelectric Point: 10.5523

>AT70790 WP_002221020.1 NZ_CP018907:c939242-938931 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT70790 NZ_CP018907:c939242-938931 [Neisseria meningitidis]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Y6JZK6