Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1134132..1134644 Replicon chromosome
Accession NZ_CP018838
Organism Streptococcus pneumoniae strain 11A

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag BUM80_RS06055 Protein ID WP_000924721.1
Coordinates 1134132..1134386 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag BUM80_RS06060 Protein ID WP_000388572.1
Coordinates 1134390..1134644 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BUM80_RS06040 1131233..1131547 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
BUM80_RS06045 1131572..1132198 - 627 WP_000775037.1 guanylate kinase -
BUM80_RS06050 1132328..1133941 - 1614 WP_000404929.1 ribonuclease Y -
BUM80_RS06055 1134132..1134386 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
BUM80_RS06060 1134390..1134644 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BUM80_RS06065 1134882..1135979 - 1098 WP_061823230.1 nucleotidyltransferase -
BUM80_RS06070 1136003..1137814 - 1812 WP_001025033.1 NACHT domain-containing protein -
BUM80_RS06075 1137855..1138595 - 741 WP_000257068.1 class I SAM-dependent methyltransferase -
BUM80_RS06080 1138915..1139268 - 354 WP_001003001.1 ribosome silencing factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T70653 WP_000924721.1 NZ_CP018838:c1134386-1134132 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T70653 NZ_CP018838:c1134386-1134132 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCGTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT70653 WP_000388572.1 NZ_CP018838:c1134644-1134390 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT70653 NZ_CP018838:c1134644-1134390 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References