Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4849898..4850555 Replicon chromosome
Accession NZ_CP018814
Organism Enterobacter cloacae complex sp. AR_0002

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AM329_RS24115 Protein ID WP_032609983.1
Coordinates 4850256..4850555 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AM329_RS24110 Protein ID WP_032609984.1
Coordinates 4849898..4850245 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM329_RS24085 (AM329_23325) 4845232..4846230 + 999 WP_022651706.1 transketolase family protein -
AM329_RS24090 (AM329_23330) 4846305..4847036 + 732 WP_022651705.1 class I SAM-dependent methyltransferase -
AM329_RS24095 (AM329_23335) 4847033..4847635 - 603 WP_022651704.1 short chain dehydrogenase -
AM329_RS24100 (AM329_23340) 4847733..4848620 + 888 WP_022651703.1 LysR family transcriptional regulator -
AM329_RS24105 (AM329_23345) 4848641..4849822 + 1182 WP_023314694.1 PLP-dependent aminotransferase family protein -
AM329_RS24110 (AM329_23350) 4849898..4850245 - 348 WP_032609984.1 HigA family addiction module antitoxin Antitoxin
AM329_RS24115 (AM329_23355) 4850256..4850555 - 300 WP_032609983.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM329_RS24120 (AM329_23360) 4850806..4852005 - 1200 WP_032609982.1 HlyD family efflux transporter periplasmic adaptor subunit -
AM329_RS24125 (AM329_23365) 4851986..4854178 - 2193 WP_032609980.1 type I secretion system permease/ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-103)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11610.24 Da        Isoelectric Point: 9.6776

>T70606 WP_032609983.1 NZ_CP018814:c4850555-4850256 [Enterobacter cloacae complex sp. AR_0002]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNIYEALSPTLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

>T70606 NZ_CP018814:c4850555-4850256 [Enterobacter cloacae complex sp. AR_0002]
ATGATTAATCATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATTCCTTTGAATCT
GGAAACAGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATA
TATATGAAGCATTGAGTCCTACGTTGAAGGGATACTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
TCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13094.06 Da        Isoelectric Point: 9.5932

>AT70606 WP_032609984.1 NZ_CP018814:c4850245-4849898 [Enterobacter cloacae complex sp. AR_0002]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEVLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWETQSNSRTQEELSRIKTVAEVMAKRKSGKPDVA

Download         Length: 348 bp

>AT70606 NZ_CP018814:c4850245-4849898 [Enterobacter cloacae complex sp. AR_0002]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGAGGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAACGATCTGGCAGAGGTGCTAAATGTACACCGCAATACCGTAAGCGCGTTGGTCAATAACAATCGCAAACTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTAATACCACTATTGAATTTTGGCTGAACTTACAGCTAAACGTTGAT
ATCTGGGAAACGCAATCTAACTCCCGCACGCAGGAGGAGTTAAGCCGGATAAAAACCGTTGCGGAAGTCATGGCGAAGCG
AAAATCCGGCAAGCCGGACGTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References