Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2792427..2793102 Replicon chromosome
Accession NZ_CP018811
Organism Paraburkholderia sp. SOS3

Toxin (Protein)


Gene name higB Uniprot ID A0A1L6HX94
Locus tag BTO02_RS12475 Protein ID WP_075157297.1
Coordinates 2792427..2792774 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1L6HY07
Locus tag BTO02_RS12480 Protein ID WP_075157298.1
Coordinates 2792767..2793102 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTO02_RS12455 2787703..2788347 - 645 WP_075157293.1 hypothetical protein -
BTO02_RS12460 2788497..2789681 - 1185 WP_075157294.1 acetyl-CoA C-acyltransferase family protein -
BTO02_RS12465 2789883..2790821 - 939 WP_075157295.1 sugar kinase -
BTO02_RS12470 2790825..2792225 - 1401 WP_075157296.1 30S ribosomal protein S12 methylthiotransferase RimO -
BTO02_RS12475 2792427..2792774 + 348 WP_075157297.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BTO02_RS12480 2792767..2793102 + 336 WP_075157298.1 helix-turn-helix domain-containing protein Antitoxin
BTO02_RS12485 2793203..2793775 - 573 WP_075157299.1 polyhydroxyalkanoate synthesis repressor PhaR -
BTO02_RS12490 2793916..2794656 - 741 WP_075157300.1 3-ketoacyl-ACP reductase -
BTO02_RS12495 2794859..2796040 - 1182 WP_075158825.1 acetyl-CoA C-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(17-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-106)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13480.58 Da        Isoelectric Point: 9.9195

>T70592 WP_075157297.1 NZ_CP018811:2792427-2792774 [Paraburkholderia sp. SOS3]
MTWNVVYFNDQVKREVFELPDGILASYLRLVDIMEEFGADLRMPHSRAMGDGLFELRPRGEEGIGRVFYCMHVNRQVVVL
HSFVKKTQETPRNELSKARKRLKEVQRSKEVVRNG

Download         Length: 348 bp

>T70592 NZ_CP018811:2792427-2792774 [Paraburkholderia sp. SOS3]
ATGACCTGGAACGTCGTTTATTTCAATGACCAGGTCAAACGCGAAGTCTTCGAACTACCCGATGGCATCCTCGCCAGCTA
TTTGCGGCTAGTCGACATCATGGAAGAATTCGGCGCCGATTTGCGTATGCCGCACTCGCGCGCGATGGGCGACGGATTGT
TCGAGTTACGTCCGCGTGGAGAGGAAGGCATCGGGCGCGTGTTCTACTGCATGCACGTCAACCGGCAGGTCGTCGTTCTG
CATTCCTTCGTCAAGAAGACGCAGGAAACGCCGCGCAACGAATTGAGCAAGGCTCGCAAGCGCTTGAAAGAAGTACAACG
TTCGAAGGAGGTAGTACGCAATGGCTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 11908.55 Da        Isoelectric Point: 9.9217

>AT70592 WP_075157298.1 NZ_CP018811:2792767-2793102 [Paraburkholderia sp. SOS3]
MAKVTAQRGGNPKGFEPVAHTKADTERLLAKPDVRAAYDALEDEYSALRVLLSARREAGLTQAEIAERMGTTASAVSRLE
ASLSSEKHSPSFATLRKYAAACGKRLVISFA

Download         Length: 336 bp

>AT70592 NZ_CP018811:2792767-2793102 [Paraburkholderia sp. SOS3]
ATGGCTAAAGTAACTGCGCAGCGCGGCGGCAATCCCAAGGGGTTCGAGCCGGTCGCTCATACGAAGGCCGACACGGAACG
GCTGCTCGCGAAACCGGATGTGCGCGCCGCGTACGACGCGCTCGAAGACGAATACTCGGCGCTGCGCGTGCTGCTTTCGG
CGCGCCGCGAAGCCGGGCTCACTCAAGCGGAGATCGCCGAGCGCATGGGGACGACCGCATCGGCCGTGTCGCGCCTCGAA
GCATCGCTTTCGAGCGAAAAGCATTCTCCGTCGTTCGCCACATTGCGCAAGTACGCCGCCGCATGCGGCAAGCGGCTCGT
CATCTCGTTTGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6HX94

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6HY07

References