Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 209988..210582 Replicon chromosome
Accession NZ_CP018811
Organism Paraburkholderia sp. SOS3

Toxin (Protein)


Gene name graT Uniprot ID A0A1L6HRV4
Locus tag BTO02_RS00945 Protein ID WP_075155425.1
Coordinates 209988..210266 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1L6HT61
Locus tag BTO02_RS00950 Protein ID WP_075155426.1
Coordinates 210280..210582 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTO02_RS00920 205886..207178 + 1293 WP_075155421.1 MFS transporter -
BTO02_RS34685 207367..207513 + 147 WP_198039169.1 hypothetical protein -
BTO02_RS00925 207532..208137 - 606 WP_075155422.1 recombinase family protein -
BTO02_RS00930 208332..208847 + 516 WP_075155423.1 hypothetical protein -
BTO02_RS00935 208952..209392 + 441 WP_075155424.1 hypothetical protein -
BTO02_RS00940 209423..209623 - 201 WP_075158498.1 KTSC domain-containing protein -
BTO02_RS00945 209988..210266 + 279 WP_075155425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BTO02_RS00950 210280..210582 + 303 WP_075155426.1 HigA family addiction module antidote protein Antitoxin
BTO02_RS00955 211074..211220 - 147 Protein_191 benzoate/H(+) symporter BenE family transporter -
BTO02_RS00960 211326..213566 - 2241 WP_083615191.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10889.48 Da        Isoelectric Point: 8.5350

>T70591 WP_075155425.1 NZ_CP018811:209988-210266 [Paraburkholderia sp. SOS3]
MIKSFRCKDTEALYKGESPKRFRAIETVAVRKLQMLEAAHQLRDLRSPPGNRLEPMHWDRPDQHSIRINGQWRLCFVWAN
DGVTEVEIVDYH

Download         Length: 279 bp

>T70591 NZ_CP018811:209988-210266 [Paraburkholderia sp. SOS3]
ATGATCAAGTCGTTCCGATGCAAGGATACCGAGGCTCTTTACAAGGGCGAGTCGCCCAAGCGCTTCCGGGCAATTGAAAC
CGTGGCTGTGCGCAAGCTCCAGATGCTCGAAGCGGCCCATCAGCTGCGAGACTTGCGCTCGCCGCCCGGCAATCGGCTCG
AACCGATGCATTGGGATCGGCCAGATCAGCACAGTATCCGCATCAACGGACAATGGCGCCTCTGTTTCGTCTGGGCGAAC
GATGGCGTCACTGAGGTCGAAATCGTCGACTATCACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11343.97 Da        Isoelectric Point: 6.4719

>AT70591 WP_075155426.1 NZ_CP018811:210280-210582 [Paraburkholderia sp. SOS3]
MAKNGMRPVHPGEVLREEFLVPLEMSVNALSLALSVPATRIHEIANERRGITADTAYRLARYFDTTPEFWMNLQTAYDLK
TLPTRAEIDRKVEPREASSA

Download         Length: 303 bp

>AT70591 NZ_CP018811:210280-210582 [Paraburkholderia sp. SOS3]
ATGGCCAAGAACGGAATGCGTCCGGTCCATCCGGGCGAAGTCTTGCGGGAAGAATTCCTCGTCCCGCTGGAAATGAGCGT
GAACGCGTTGTCGCTGGCGCTGAGCGTGCCGGCTACGCGCATACACGAGATCGCGAACGAGCGGCGCGGCATCACCGCCG
ACACCGCCTATCGCCTCGCGCGCTATTTCGATACGACGCCCGAGTTCTGGATGAACCTGCAGACAGCGTACGACCTGAAG
ACGTTGCCGACGCGCGCGGAGATCGATCGCAAGGTTGAGCCGCGCGAAGCATCGAGTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6HRV4

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6HT61

References