Detailed information of TA system TA070565

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-rdlD/SymE(toxin)
• Location: 4094781..4095193
• Replicon: chromosome
• Accession: NZ_CP018801
• Organism: Escherichia coli strain tolC-

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: BTD92_RS21955
• Protein ID: WP_000132601.1
• Coordinates: 4094852..4095193 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4094781..4094857 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTD92_RS21945	4091644..4093233	+	1590	WP_001063204.1	type I restriction-modification system methyltransferase	-
BTD92_RS21950	4093230..4094624	+	1395	WP_001272447.1	type I restriction-modification system specificity subunit	-
-	4094781..4094857	-	77	NuclAT_15	-	Antitoxin
-	4094781..4094857	-	77	NuclAT_15	-	Antitoxin
-	4094781..4094857	-	77	NuclAT_15	-	Antitoxin
-	4094781..4094857	-	77	NuclAT_15	-	Antitoxin
-	4094781..4094857	-	77	NuclAT_16	-	Antitoxin
-	4094781..4094857	-	77	NuclAT_16	-	Antitoxin
-	4094781..4094857	-	77	NuclAT_16	-	Antitoxin
-	4094781..4094857	-	77	NuclAT_16	-	Antitoxin
BTD92_RS21955	4094852..4095193	+	342	WP_000132601.1	endoribonuclease SymE	Toxin
BTD92_RS21960	4095355..4096734	+	1380	Protein_3921	5-methylcytosine-specific restriction endonuclease subunit McrB	-
BTD92_RS21965	4096734..4097780	+	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T70565 WP_000132601.1 NZ_CP018801:4094852-4095193 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T70565 NZ_CP018801:4094852-4095193 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT70565 NZ_CP018801:c4094857-4094781 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin