Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1739255..1739844 Replicon chromosome
Accession NZ_CP018787
Organism Oxalobacter formigenes strain HC-1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag BRW83_RS08385 Protein ID WP_005880108.1
Coordinates 1739255..1739533 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BRW83_RS08390 Protein ID WP_005880107.1
Coordinates 1739545..1739844 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BRW83_RS08360 1734382..1734597 - 216 WP_005880112.1 hypothetical protein -
BRW83_RS08365 1734756..1735574 - 819 WP_050757770.1 sel1 repeat family protein -
BRW83_RS08370 1735639..1737348 - 1710 WP_086131830.1 hypothetical protein -
BRW83_RS08375 1737589..1738782 - 1194 WP_005880109.1 MFS transporter -
BRW83_RS08385 1739255..1739533 + 279 WP_005880108.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BRW83_RS08390 1739545..1739844 + 300 WP_005880107.1 HigA family addiction module antidote protein Antitoxin
BRW83_RS08395 1739990..1741057 - 1068 WP_005880106.1 porin -
BRW83_RS08405 1741381..1742460 - 1080 WP_036602709.1 porin -
BRW83_RS08415 1742720..1743730 - 1011 WP_005880103.1 ADP-glyceromanno-heptose 6-epimerase -
BRW83_RS08420 1744126..1744515 + 390 WP_005880102.1 NirD/YgiW/YdeI family stress tolerance protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-86)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10670.21 Da        Isoelectric Point: 9.7825

>T70527 WP_005880108.1 NZ_CP018787:1739255-1739533 [Oxalobacter formigenes]
MIKSFTCPDTQDLFAGKTVPRFVNIRSVAERKLQMIHRATGINDLRIPPNNRLEALKGDRKGQYSIRINDQWRICFTFDN
GQAFDVSIVDYH

Download         Length: 279 bp

>T70527 NZ_CP018787:1739255-1739533 [Oxalobacter formigenes]
ATGATTAAATCGTTCACATGTCCGGATACACAAGACCTGTTTGCCGGTAAAACCGTTCCCCGGTTTGTCAACATCCGGTC
AGTAGCGGAACGCAAACTCCAGATGATTCACAGGGCTACGGGCATAAACGATTTACGAATTCCACCCAATAACCGCCTTG
AAGCGTTAAAAGGCGATAGAAAAGGTCAATACAGCATAAGAATTAATGACCAGTGGCGCATTTGTTTCACGTTCGATAAT
GGACAGGCTTTTGATGTTTCGATTGTCGATTACCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11408.12 Da        Isoelectric Point: 6.4636

>AT70527 WP_005880107.1 NZ_CP018787:1739545-1739844 [Oxalobacter formigenes]
MDNIINGMRPIHPGEILREEFLSPMNLSSNALAIELHVPAPRINEIVRERRSITADTALRLARYFGTSAEFWMGLQDDYD
LKTCQRKLDETLGRIIPRQ

Download         Length: 300 bp

>AT70527 NZ_CP018787:1739545-1739844 [Oxalobacter formigenes]
ATGGATAACATTATTAATGGCATGAGGCCAATACATCCGGGGGAAATTCTCAGAGAAGAATTTCTGTCCCCGATGAACTT
GTCTTCCAATGCACTGGCCATTGAACTGCACGTCCCCGCGCCACGGATAAATGAAATTGTCCGTGAACGCAGAAGCATCA
CGGCAGATACCGCTTTACGTCTTGCCCGTTATTTTGGAACAAGTGCTGAATTCTGGATGGGCTTGCAAGATGATTACGAT
CTGAAAACCTGCCAGAGAAAACTCGATGAAACGCTTGGCCGGATTATTCCGCGCCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References