70506

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 60307..60908 Replicon chromosome
Accession NZ_CP018779
Organism Brucella pituitosa strain AA2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BUE85_RS00255 Protein ID WP_079210515.1
Coordinates 60307..60633 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BUE85_RS00260 Protein ID WP_079210516.1
Coordinates 60630..60908 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BUE85_RS00230 55529..55966 + 438 WP_079210511.1 cupin domain-containing protein -
BUE85_RS00235 56062..56508 + 447 WP_025090397.1 carboxymuconolactone decarboxylase family protein -
BUE85_RS00240 56553..57188 - 636 WP_079210512.1 TetR/AcrR family transcriptional regulator -
BUE85_RS00245 57266..58297 + 1032 WP_079210513.1 HlyD family secretion protein -
BUE85_RS00250 58297..59961 + 1665 WP_079210514.1 DHA2 family efflux MFS transporter permease subunit -
BUE85_RS00255 60307..60633 + 327 WP_079210515.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BUE85_RS00260 60630..60908 + 279 WP_079210516.1 helix-turn-helix domain-containing protein Antitoxin
BUE85_RS00265 61039..61935 - 897 Protein_52 DUF4172 domain-containing protein -
BUE85_RS00270 62255..63100 + 846 WP_202818640.1 hypothetical protein -
BUE85_RS00275 63446..64237 - 792 WP_079210517.1 IS21-like element helper ATPase IstB -
BUE85_RS00280 64227..65753 - 1527 WP_152027216.1 IS21 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 60307..76731 16424


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12291.57 Da        Isoelectric Point: 10.2868

>T70506 WP_079210515.1 NZ_CP018779:60307-60633 [Brucella pituitosa]
MRWIVETLDDTVDAEIEGLPAGLQARLIRLMEMVESVGLEQLHEPHVKHLEGKLWELRAKAMEGIARGLYVTVTGRRVVI
LHVFVKKSQKTPKSALDLAKQRMKQVKP

Download         Length: 327 bp

>T70506 NZ_CP018779:60307-60633 [Brucella pituitosa]
ATGCGATGGATAGTAGAAACGCTTGACGACACTGTGGATGCTGAAATTGAAGGGCTTCCTGCTGGATTGCAGGCACGTCT
TATCCGTTTAATGGAAATGGTCGAGAGCGTTGGTTTAGAGCAATTGCATGAGCCTCATGTCAAGCATTTAGAGGGAAAGC
TCTGGGAGCTTCGCGCTAAAGCAATGGAAGGAATTGCGCGGGGTCTGTACGTTACTGTTACTGGACGCCGCGTTGTCATT
CTTCATGTATTTGTCAAGAAATCGCAGAAAACACCTAAGAGTGCCTTAGATTTAGCAAAGCAGCGAATGAAACAGGTAAA
GCCATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10194.68 Da        Isoelectric Point: 9.9995

>AT70506 WP_079210516.1 NZ_CP018779:60630-60908 [Brucella pituitosa]
MTRIADLKKRLMNDPEFRKEYEEADAEFSLVEALVKARADAKMSQADVAKRIGTTQSAIARLEGGKVSPSISTLRRYAEA
TGSKLQINLIHS

Download         Length: 279 bp

>AT70506 NZ_CP018779:60630-60908 [Brucella pituitosa]
ATGACCAGGATAGCAGACCTAAAAAAGCGCCTCATGAATGATCCGGAATTCCGGAAGGAATATGAAGAAGCGGATGCTGA
GTTCAGTCTTGTCGAAGCTCTTGTGAAGGCGAGGGCCGACGCAAAGATGTCGCAAGCTGATGTAGCAAAACGTATCGGCA
CGACCCAATCAGCTATTGCTCGGCTTGAAGGCGGTAAGGTTTCTCCGTCCATTTCTACATTACGTCGATACGCAGAGGCC
ACAGGGTCAAAACTGCAAATTAATCTGATCCATTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References