Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2976589..2977237 Replicon chromosome
Accession NZ_CP018778
Organism Mycobacterium tuberculosis strain DK9897

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag BTU11_RS14600 Protein ID WP_003899414.1
Coordinates 2976589..2976912 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag BTU11_RS14605 Protein ID WP_003899415.1
Coordinates 2976992..2977237 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTU11_RS14575 2972163..2973424 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
BTU11_RS21855 2973451..2973636 - 186 WP_015630490.1 hypothetical protein -
BTU11_RS14585 2973798..2975237 - 1440 WP_003899411.1 phage major capsid protein -
BTU11_RS14590 2975245..2975778 - 534 WP_003899412.1 HK97 family phage prohead protease -
BTU11_RS14595 2975931..2976422 - 492 WP_003900541.1 phage terminase small subunit P27 family -
BTU11_RS14600 2976589..2976912 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
BTU11_RS14605 2976992..2977237 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
BTU11_RS14610 2977234..2978661 - 1428 WP_031664026.1 DUF3631 domain-containing protein -
BTU11_RS14615 2978663..2979055 - 393 WP_003899417.1 DUF2742 domain-containing protein -
BTU11_RS14620 2979052..2979312 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
BTU11_RS14625 2979329..2979691 - 363 WP_003900543.1 hypothetical protein -
BTU11_RS14630 2979694..2980821 - 1128 WP_003899420.1 site-specific integrase -
BTU11_RS14635 2980966..2981193 - 228 WP_003899421.1 hypothetical protein -
BTU11_RS14640 2981190..2981579 - 390 WP_003899422.1 hypothetical protein -
BTU11_RS14645 2981485..2981757 + 273 WP_003900544.1 hypothetical protein -
BTU11_RS14650 2981856..2982089 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2970554..2980821 10267


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T70494 WP_003899414.1 NZ_CP018778:c2976912-2976589 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T70494 NZ_CP018778:c2976912-2976589 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT70494 WP_003899415.1 NZ_CP018778:c2977237-2976992 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT70494 NZ_CP018778:c2977237-2976992 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References