Detailed information of TA system TA070433

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2062525..2062832
• Replicon: chromosome
• Accession: NZ_CP018768
• Organism: Staphylococcus aureus strain UCI 28 isolate ST5

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: BSG37_RS10605
• Protein ID: WP_011447039.1
• Coordinates: 2062656..2062832 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2062525..2062664 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BSG37_RS10550	2057939..2058124	+	186	WP_031784682.1	hypothetical protein	-
BSG37_RS10555	2058177..2058527	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
BSG37_RS10560	2059212..2059661	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
BSG37_RS15140	2059756..2060091	-	336	Protein_1953	SH3 domain-containing protein	-
BSG37_RS10585	2060741..2061232	-	492	WP_000919350.1	staphylokinase	-
BSG37_RS10590	2061423..2062178	-	756	WP_000861038.1	CHAP domain-containing protein	-
BSG37_RS10595	2062190..2062444	-	255	WP_000611512.1	phage holin	-
BSG37_RS10600	2062496..2062603	+	108	WP_001791821.1	hypothetical protein	-
-	2062525..2062664	+	140	NuclAT_0	-	Antitoxin
-	2062525..2062664	+	140	NuclAT_0	-	Antitoxin
-	2062525..2062664	+	140	NuclAT_0	-	Antitoxin
-	2062525..2062664	+	140	NuclAT_0	-	Antitoxin
BSG37_RS10605	2062656..2062832	-	177	WP_011447039.1	putative holin-like toxin	Toxin
BSG37_RS10610	2062982..2063278	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
BSG37_RS10615	2063336..2063623	-	288	WP_001040261.1	hypothetical protein	-
BSG37_RS10620	2063670..2063822	-	153	WP_001153681.1	hypothetical protein	-
BSG37_RS10625	2063812..2067597	-	3786	WP_000582154.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2058177..2108671	50494

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T70433 WP_011447039.1 NZ_CP018768:c2062832-2062656 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T70433 NZ_CP018768:c2062832-2062656 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT70433 NZ_CP018768:2062525-2062664 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin