Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2585954..2586138 Replicon chromosome
Accession NZ_CP018766
Organism Staphylococcus aureus strain UCI62

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag BSG38_RS13650 Protein ID WP_000482652.1
Coordinates 2586031..2586138 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2585954..2586014 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSG38_RS13625 2581409..2581576 - 168 Protein_2514 hypothetical protein -
BSG38_RS13635 2581807..2583540 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
BSG38_RS13640 2583565..2585328 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2585954..2586014 + 61 - - Antitoxin
BSG38_RS13650 2586031..2586138 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
BSG38_RS13655 2586272..2586658 - 387 WP_000779360.1 flippase GtxA -
BSG38_RS13660 2586926..2588068 + 1143 WP_001176863.1 glycerate kinase -
BSG38_RS13665 2588128..2588787 + 660 WP_000831298.1 membrane protein -
BSG38_RS13670 2588969..2590180 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
BSG38_RS13675 2590303..2590776 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T70425 WP_000482652.1 NZ_CP018766:c2586138-2586031 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T70425 NZ_CP018766:c2586138-2586031 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT70425 NZ_CP018766:2585954-2586014 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References