Detailed information of TA system TA070410

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1640211..1640790
• Replicon: chromosome
• Accession: NZ_CP018766
• Organism: Staphylococcus aureus strain UCI62

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: BSG38_RS08330
• Protein ID: WP_001025401.1
• Coordinates: 1640545..1640790 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1640211..1640576 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BSG38_RS08290	1636954..1637511	-	558	WP_000645042.1	DUF2815 family protein	-
BSG38_RS08295	1637537..1638703	-	1167	WP_000762547.1	DUF2800 domain-containing protein	-
BSG38_RS08300	1638700..1639062	-	363	WP_031785938.1	hypothetical protein	-
BSG38_RS08305	1639077..1639400	-	324	WP_000175001.1	hypothetical protein	-
BSG38_RS08310	1639479..1639640	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
BSG38_RS08315	1639653..1639916	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
BSG38_RS08320	1639941..1640156	-	216	WP_001097552.1	hypothetical protein	-
BSG38_RS08325	1640211..1640576	+	366	WP_001128433.1	hypothetical protein	Antitoxin
BSG38_RS08330	1640545..1640790	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
BSG38_RS08335	1640846..1641055	+	210	WP_000642492.1	hypothetical protein	-
BSG38_RS08340	1641045..1641188	-	144	WP_000939498.1	hypothetical protein	-
BSG38_RS08345	1641217..1641993	-	777	WP_001148544.1	Rha family transcriptional regulator	-
BSG38_RS08350	1642007..1642243	-	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
BSG38_RS08355	1642395..1642709	+	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
BSG38_RS08360	1642722..1643183	+	462	WP_000525004.1	hypothetical protein	-
BSG38_RS08365	1643201..1643785	+	585	WP_000825948.1	hypothetical protein	-
BSG38_RS08370	1644015..1644161	+	147	WP_001013104.1	hypothetical protein	-
BSG38_RS08375	1644158..1644772	-	615	WP_000191459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1600815..1663728	62913

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T70410 WP_001025401.1 NZ_CP018766:c1640790-1640545 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T70410 NZ_CP018766:c1640790-1640545 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT70410 NZ_CP018766:1640211-1640576 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin