Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 3230494..3231108 Replicon chromosome
Accession NZ_CP018756
Organism Stenotrophomonas maltophilia strain AA1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BTU49_RS14725 Protein ID WP_079223058.1
Coordinates 3230494..3230808 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BTU49_RS14730 Protein ID WP_079223060.1
Coordinates 3230812..3231108 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTU49_RS14705 3226389..3226775 - 387 WP_046987316.1 RidA family protein -
BTU49_RS14710 3226910..3229072 - 2163 WP_079223044.1 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -
BTU49_RS14715 3229178..3229474 - 297 WP_079223054.1 DNA-directed RNA polymerase subunit omega -
BTU49_RS14720 3229585..3230250 - 666 WP_079223056.1 guanylate kinase -
BTU49_RS14725 3230494..3230808 + 315 WP_079223058.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BTU49_RS14730 3230812..3231108 + 297 WP_079223060.1 helix-turn-helix domain-containing protein Antitoxin
BTU49_RS14735 3231132..3231551 - 420 WP_079223062.1 hypothetical protein -
BTU49_RS14740 3231641..3232501 - 861 WP_079223064.1 YicC family protein -
BTU49_RS14745 3232626..3233351 + 726 WP_079223066.1 ribonuclease PH -
BTU49_RS14750 3233348..3233734 + 387 WP_079223068.1 VOC family protein -
BTU49_RS14755 3233734..3234330 + 597 WP_079223070.1 RdgB/HAM1 family non-canonical purine NTP pyrophosphatase -
BTU49_RS14760 3234418..3235620 + 1203 WP_192851851.1 radical SAM family heme chaperone HemW -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-73)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11537.26 Da        Isoelectric Point: 8.3804

>T70388 WP_079223058.1 NZ_CP018756:3230494-3230808 [Stenotrophomonas maltophilia]
MIFVETPTFTRLITALMSDEDYGAFQTGLAANPEAGDLIEGTGGLRKIRVALPGRGKRGGARIIYYYFVTASQIVLLLAY
PKNDQDDLTADQKKALRNIIENWK

Download         Length: 315 bp

>T70388 NZ_CP018756:3230494-3230808 [Stenotrophomonas maltophilia]
ATGATCTTCGTCGAAACGCCGACGTTCACCCGCCTCATCACGGCCCTGATGTCGGACGAGGACTACGGTGCCTTTCAAAC
GGGGTTGGCGGCCAATCCAGAGGCCGGCGACCTGATCGAAGGTACCGGCGGCCTGCGCAAGATCCGCGTCGCCCTGCCAG
GGCGAGGAAAGCGTGGTGGTGCCCGCATCATCTACTACTACTTCGTCACGGCGTCCCAGATCGTTCTGCTCCTAGCCTAC
CCAAAGAATGACCAGGACGATCTCACAGCAGATCAGAAGAAAGCGCTGCGGAACATCATCGAAAACTGGAAGTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10910.46 Da        Isoelectric Point: 10.4369

>AT70388 WP_079223060.1 NZ_CP018756:3230812-3231108 [Stenotrophomonas maltophilia]
MDNHLFAELMGSVTEANEILKGERSPSRERHVSPMEVRAIRQATGLSQQKFADIIRVDVGTLRNWEQGRRDPTGPARALL
HIIKTNPQGALRALAEAI

Download         Length: 297 bp

>AT70388 NZ_CP018756:3230812-3231108 [Stenotrophomonas maltophilia]
ATGGACAACCATCTTTTTGCCGAACTCATGGGCAGCGTTACCGAAGCCAACGAGATCCTGAAGGGTGAGCGCAGCCCGTC
GCGCGAGCGCCATGTCAGCCCGATGGAAGTTCGCGCCATCCGACAGGCCACAGGTCTTTCCCAGCAGAAATTCGCAGACA
TCATCCGCGTGGATGTGGGAACGCTGCGCAACTGGGAACAGGGACGGCGTGATCCGACGGGCCCCGCGCGCGCGCTGCTG
CACATCATCAAGACCAATCCGCAAGGAGCACTGCGGGCGCTGGCGGAAGCAATCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References