Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2827139..2827654 Replicon chromosome
Accession NZ_CP018731
Organism Xanthomonas hortorum pv. gardneri strain ICMP 7383

Toxin (Protein)


Gene name higB Uniprot ID A0A1L5Y3A2
Locus tag BI317_RS13190 Protein ID WP_006450902.1
Coordinates 2827448..2827654 (-) Length 69 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6V7E8T8
Locus tag BI317_RS13185 Protein ID WP_074057535.1
Coordinates 2827139..2827438 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BI317_RS13160 2822613..2823497 + 885 WP_006451802.1 MinD/ParA family protein -
BI317_RS13165 2823494..2824267 + 774 WP_023903918.1 RNA polymerase sigma factor FliA -
BI317_RS13170 2824303..2824695 + 393 WP_002813536.1 chemotaxis response regulator CheY -
BI317_RS13175 2824695..2825321 + 627 WP_006450905.1 protein phosphatase CheZ -
BI317_RS13180 2825324..2826982 + 1659 WP_055826896.1 chemotaxis protein CheA -
BI317_RS13185 2827139..2827438 - 300 WP_074057535.1 HigA family addiction module antidote protein Antitoxin
BI317_RS13190 2827448..2827654 - 207 WP_006450902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BI317_RS13195 2828566..2829306 + 741 WP_006452732.1 flagellar motor protein -
BI317_RS13200 2829314..2830303 + 990 WP_006452731.1 flagellar motor protein MotD -
BI317_RS13205 2830305..2831087 + 783 WP_006452730.1 ParA family protein -
BI317_RS13210 2831084..2832334 + 1251 WP_074057536.1 chemotaxis protein CheW -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-68)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-67)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7818.83 Da        Isoelectric Point: 6.2041

>T70369 WP_006450902.1 NZ_CP018731:c2827654-2827448 [Xanthomonas hortorum pv. gardneri]
MQAVAERKLQLLDSAQTLEFLRSPPGNRFELLAGTRAGQHSIRINDQWRVCFVWTDAGPEHVEIVDYH

Download         Length: 207 bp

>T70369 NZ_CP018731:c2827654-2827448 [Xanthomonas hortorum pv. gardneri]
ATGCAAGCTGTAGCCGAACGGAAGCTGCAATTGCTGGATTCGGCGCAGACGCTGGAGTTCTTGCGCAGCCCGCCGGGCAA
TCGGTTTGAGCTTCTTGCGGGTACGCGTGCAGGTCAGCACAGCATCCGCATCAATGACCAATGGCGTGTGTGCTTTGTCT
GGACTGACGCCGGCCCCGAGCACGTTGAGATTGTCGATTACCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10900.54 Da        Isoelectric Point: 10.7753

>AT70369 WP_074057535.1 NZ_CP018731:c2827438-2827139 [Xanthomonas hortorum pv. gardneri]
MRPNNKLRAIHPGEILREDFMLPLGLTINGLARALDVPATRIHSIVHGERAISADTAARLARHFGGDAASWLALQATYEL
KTLPNRSEIERNVQPRVAA

Download         Length: 300 bp

>AT70369 NZ_CP018731:c2827438-2827139 [Xanthomonas hortorum pv. gardneri]
ATGCGACCCAACAACAAACTGCGCGCCATCCATCCCGGCGAAATCCTGCGGGAAGATTTCATGCTGCCGCTGGGGCTGAC
CATTAACGGCCTGGCGCGGGCGCTGGATGTACCGGCAACGCGCATCCACAGCATCGTGCATGGCGAGCGTGCCATCAGCG
CCGATACCGCAGCGCGGCTTGCACGCCACTTCGGTGGCGATGCGGCGTCCTGGCTCGCGCTGCAGGCCACGTATGAACTC
AAGACCTTGCCCAACCGCAGCGAGATCGAGCGCAACGTGCAGCCGCGTGTGGCGGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L5Y3A2

Antitoxin

Source ID Structure
AlphaFold DB A0A6V7E8T8

References