Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 15559..16216 | Replicon | plasmid pKp_Goe_304-2 |
| Accession | NZ_CP018722 | ||
| Organism | Klebsiella pneumoniae strain KP_Goe_828304 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | BB787_RS29500 | Protein ID | WP_000270043.1 |
| Coordinates | 15559..15909 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | BB787_RS29505 | Protein ID | WP_000124640.1 |
| Coordinates | 15914..16216 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BB787_RS29445 | 10870..11049 | + | 180 | Protein_14 | helix-turn-helix transcriptional regulator | - |
| BB787_RS29450 | 11114..11818 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| BB787_RS29460 | 12033..12530 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| BB787_RS29465 | 12533..13021 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| BB787_RS29470 | 13118..13453 | + | 336 | WP_000683476.1 | hypothetical protein | - |
| BB787_RS29475 | 13468..13938 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| BB787_RS29480 | 13931..14302 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| BB787_RS29485 | 14313..14507 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| BB787_RS29495 | 14848..15396 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| BB787_RS29500 | 15559..15909 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| BB787_RS29505 | 15914..16216 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| BB787_RS29510 | 16243..16536 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| BB787_RS29515 | 16624..16896 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| BB787_RS29520 | 16954..17481 | - | 528 | WP_001236377.1 | thermonuclease family protein | - |
| BB787_RS29530 | 17712..18569 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| BB787_RS29535 | 18556..18786 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| BB787_RS29540 | 18786..19304 | - | 519 | WP_000210756.1 | nitrite reductase | - |
| BB787_RS29545 | 19301..19747 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| BB787_RS29550 | 19747..20106 | - | 360 | WP_000422768.1 | hypothetical protein | - |
| BB787_RS29555 | 20163..20591 | - | 429 | WP_000591074.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | floR / sul1 / qacE / aac(6')-Ib / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) | - | 1..96073 | 96073 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T70360 WP_000270043.1 NZ_CP018722:15559-15909 [Klebsiella pneumoniae]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T70360 NZ_CP018722:15559-15909 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT70360 WP_000124640.1 NZ_CP018722:15914-16216 [Klebsiella pneumoniae]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT70360 NZ_CP018722:15914-16216 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|