Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 37271..37928 | Replicon | plasmid pKp_Goe_021-2 |
| Accession | NZ_CP018716 | ||
| Organism | Klebsiella pneumoniae strain Kp_Goe_152021 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | BB786_RS29635 | Protein ID | WP_000270043.1 |
| Coordinates | 37578..37928 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | BB786_RS29630 | Protein ID | WP_000124640.1 |
| Coordinates | 37271..37573 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BB786_RS29580 | 32896..33324 | + | 429 | WP_000591074.1 | hypothetical protein | - |
| BB786_RS29585 | 33381..33740 | + | 360 | WP_000422768.1 | hypothetical protein | - |
| BB786_RS29590 | 33740..34186 | + | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| BB786_RS29595 | 34183..34701 | + | 519 | WP_000210756.1 | nitrite reductase | - |
| BB786_RS29600 | 34701..34931 | + | 231 | WP_000972663.1 | hypothetical protein | - |
| BB786_RS29605 | 34918..35775 | + | 858 | WP_001167032.1 | hypothetical protein | - |
| BB786_RS29615 | 36006..36533 | + | 528 | WP_001236377.1 | thermonuclease family protein | - |
| BB786_RS29620 | 36591..36863 | + | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| BB786_RS29625 | 36951..37244 | + | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| BB786_RS29630 | 37271..37573 | - | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| BB786_RS29635 | 37578..37928 | - | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| BB786_RS29640 | 38091..38639 | + | 549 | WP_001061574.1 | transcriptional regulator | - |
| BB786_RS29650 | 38980..39174 | + | 195 | WP_000343597.1 | hypothetical protein | - |
| BB786_RS29655 | 39185..39556 | + | 372 | WP_000516916.1 | hypothetical protein | - |
| BB786_RS29660 | 39549..40019 | + | 471 | WP_001281821.1 | hypothetical protein | - |
| BB786_RS29665 | 40034..40369 | - | 336 | WP_000683476.1 | hypothetical protein | - |
| BB786_RS29670 | 40466..40954 | + | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| BB786_RS29675 | 40957..41454 | + | 498 | WP_000062185.1 | hypothetical protein | - |
| BB786_RS29685 | 41669..42373 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| BB786_RS29690 | 42438..42617 | - | 180 | Protein_53 | helix-turn-helix transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | aac(6')-Ib / qacE / sul1 / floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 | - | 1..96074 | 96074 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T70337 WP_000270043.1 NZ_CP018716:c37928-37578 [Klebsiella pneumoniae]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T70337 NZ_CP018716:c37928-37578 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT70337 WP_000124640.1 NZ_CP018716:c37573-37271 [Klebsiella pneumoniae]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT70337 NZ_CP018716:c37573-37271 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|