Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 7625875..7626484 Replicon chromosome
Accession NZ_CP018632
Organism Granulosicoccus antarcticus IMCC3135

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IMCC3135_RS33120 Protein ID WP_088921491.1
Coordinates 7625875..7626153 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IMCC3135_RS33125 Protein ID WP_088921492.1
Coordinates 7626179..7626484 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMCC3135_RS33105 7621106..7623487 + 2382 WP_169727561.1 FG-GAP repeat protein -
IMCC3135_RS33110 7623702..7624241 + 540 WP_088921489.1 hypothetical protein -
IMCC3135_RS33115 7624596..7625633 + 1038 WP_088921490.1 hypothetical protein -
IMCC3135_RS33120 7625875..7626153 + 279 WP_088921491.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IMCC3135_RS33125 7626179..7626484 + 306 WP_088921492.1 HigA family addiction module antidote protein Antitoxin
IMCC3135_RS33130 7626605..7627939 - 1335 WP_205738098.1 group II intron reverse transcriptase/maturase -
IMCC3135_RS34895 7627971..7628186 - 216 WP_205737829.1 hypothetical protein -
IMCC3135_RS33140 7628697..7628990 + 294 WP_088921493.1 BrnT family toxin -
IMCC3135_RS33145 7628987..7629217 + 231 WP_088921494.1 BrnA antitoxin family protein -
IMCC3135_RS34435 7629512..7630249 + 738 WP_157736508.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 7624596..7635456 10860


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-96)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 11123.67 Da        Isoelectric Point: 8.9505

>T70135 WP_088921491.1 NZ_CP018632:7625875-7626153 [Granulosicoccus antarcticus IMCC3135]
MIRSFKDKKTARFFEGEDVKDFRSFVDQLARRLTYLNEVEELLDLRELRSNRIEALVGKRKGQYSIRINKQWRLCFRWGP
DGPEDVEVVDYH

Download         Length: 279 bp

>T70135 NZ_CP018632:7625875-7626153 [Granulosicoccus antarcticus IMCC3135]
ATGATCAGAAGCTTCAAAGACAAGAAGACTGCGCGGTTTTTTGAAGGTGAGGATGTAAAGGACTTTCGTAGCTTTGTTGA
CCAATTGGCAAGAAGATTGACCTACCTGAACGAGGTCGAAGAATTACTGGATTTACGAGAGCTTAGGAGCAATCGAATCG
AGGCACTTGTCGGTAAGCGGAAAGGGCAATACAGCATTCGAATAAACAAGCAATGGCGTCTTTGTTTTCGGTGGGGACCA
GATGGCCCTGAGGATGTCGAAGTTGTTGATTATCATTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11359.07 Da        Isoelectric Point: 9.7727

>AT70135 WP_088921492.1 NZ_CP018632:7626179-7626484 [Granulosicoccus antarcticus IMCC3135]
MNRRNGMRPVHPGEILREEMEELEMSARAMAEALNVPANRVSAILNGTRGITADTALRLSRYLGTTPEVWMNLQKSYELR
AAEIEAGKDIEKQIKPRPRAA

Download         Length: 306 bp

>AT70135 NZ_CP018632:7626179-7626484 [Granulosicoccus antarcticus IMCC3135]
ATGAATCGTCGAAATGGCATGCGTCCAGTACACCCTGGAGAAATTCTCCGAGAGGAGATGGAAGAATTGGAAATGTCTGC
TCGTGCAATGGCAGAAGCACTCAATGTACCTGCCAACAGAGTAAGTGCAATCCTGAATGGAACTCGCGGTATCACTGCTG
ATACTGCGCTGAGGTTATCCCGCTACCTGGGTACGACACCCGAGGTATGGATGAATCTACAGAAAAGCTATGAACTGAGA
GCCGCTGAGATAGAGGCGGGAAAGGACATAGAAAAACAAATAAAGCCACGCCCCAGAGCTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References