Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 6537496..6537950 Replicon chromosome
Accession NZ_CP018632
Organism Granulosicoccus antarcticus IMCC3135

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IMCC3135_RS28235 Protein ID WP_088920628.1
Coordinates 6537496..6537663 (+) Length 56 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag IMCC3135_RS28240 Protein ID WP_088920629.1
Coordinates 6537669..6537950 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMCC3135_RS28215 6532978..6533738 + 761 Protein_5561 IS5 family transposase -
IMCC3135_RS28220 6533731..6536430 - 2700 WP_088920625.1 type I restriction endonuclease subunit R -
IMCC3135_RS28225 6536730..6537065 + 336 WP_088920626.1 type II toxin-antitoxin system RelE/ParE family toxin -
IMCC3135_RS28230 6537062..6537337 + 276 WP_088920627.1 XRE family transcriptional regulator -
IMCC3135_RS28235 6537496..6537663 + 168 WP_088920628.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IMCC3135_RS28240 6537669..6537950 + 282 WP_088920629.1 HigA family addiction module antidote protein Antitoxin
IMCC3135_RS28245 6538116..6538496 - 381 WP_088920630.1 hypothetical protein -
IMCC3135_RS28250 6538654..6540030 - 1377 WP_088920631.1 Fic family protein -
IMCC3135_RS28255 6540265..6540600 - 336 WP_088920632.1 hypothetical protein -
IMCC3135_RS28260 6540581..6540859 - 279 WP_088920633.1 restriction endonuclease subunit S -
IMCC3135_RS28265 6540968..6542443 - 1476 WP_088920634.1 IS66 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(8-54)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-83)


Sequences

Toxin        


Download         Length: 56 a.a.        Molecular weight: 6529.43 Da        Isoelectric Point: 7.2021

>T70134 WP_088920628.1 NZ_CP018632:6537496-6537663 [Granulosicoccus antarcticus IMCC3135]
ISLVQLRKSPPGNRLEKLTGDLEGFHSIRINQQWRLIFRWIDGSPEDVEIVDYHR

Download         Length: 168 bp

>T70134 NZ_CP018632:6537496-6537663 [Granulosicoccus antarcticus IMCC3135]
ATCAGCCTTGTGCAACTGCGAAAGTCGCCACCTGGAAACAGATTGGAAAAACTAACAGGGGACCTGGAAGGCTTTCATAG
CATCCGCATCAATCAACAATGGCGATTGATTTTCAGATGGATAGATGGAAGTCCTGAGGATGTTGAAATCGTTGATTACC
ATAGGTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10520.24 Da        Isoelectric Point: 9.8659

>AT70134 WP_088920629.1 NZ_CP018632:6537669-6537950 [Granulosicoccus antarcticus IMCC3135]
MLPNKRTSTHPGKILLHEFLEPLELSQSEFARHLSIPIQRVNELIKGKRGITPDTAWLLSTALGTTPEFWMNLQTSYELS
SIEPPKGIKRLVA

Download         Length: 282 bp

>AT70134 NZ_CP018632:6537669-6537950 [Granulosicoccus antarcticus IMCC3135]
ATGCTACCCAATAAAAGAACATCAACGCACCCAGGAAAAATTCTACTGCATGAGTTTCTGGAGCCACTGGAGCTATCGCA
GTCCGAATTCGCTCGTCATTTGAGCATCCCCATACAACGCGTTAACGAATTAATCAAAGGCAAGCGCGGAATTACGCCTG
ACACAGCGTGGTTACTCTCAACAGCACTTGGCACGACACCGGAGTTCTGGATGAACTTGCAGACAAGCTACGAATTGTCG
TCGATCGAGCCTCCCAAGGGCATTAAACGTTTGGTGGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References